Année 2001

(voir aussi 2004 2003 2002 2000 1999 1998 1997 1996 1995)

1.- ARTICLES DANS REVUES INTERNATIONALES

3.- PRESENTATIONS DANS DES CONGRES INTERNATIONAUX

4.-PRESENTATIONS DANS DES CONGRES NATIONAUX

1.- ARTICLES DANS REVUES INTERNATIONALES

PARTIAL CRICOIDECTOMY WITH PRIMARY THYROTRACHEAL ANASTOMOSIS FOR POSTINTUBATION SUBGLOTTIC STENOSIS
P. MACCHIARINI, JP. VERHOYE, A. CHAPELIER, E. FADEL, P. DARTEVELLE

J. Thorac Cardiovasc Surg 2001;121:68-76

OBJECTIVE: We describe a Pearson-type technique and evaluate its results for postintubation subglottic stenosis. METHODS: Forty-five patients underwent a partial cricoidectomy with primary thyrotracheal anastomosis, and 5 underwent simultaneous repair of a tracheoesophageal fistula as well. Twenty-four (53%) patients were referred to us after initial conservative (n = 21) or operative (n = 3) management. There were 27 cuff lesions, 7 stomal lesions, and 11 at both levels. The upper limit of the stenosis was 1.5 cm (range, 1-2.5 cm) below the cords, and the subglottic diameter was reduced by 60% in 38 (84%) of the patients. The length of airway resection ranged from 2 to 6 cm (median, 3 cm). Despite 23 thyrohyoid or suprahyoid releases, 8 anastomoses were under tension. RESULTS: Thirty-seven (82%) patients were extubated after the operation (n = 30) or within 24 hours (n = 7). Six patients required postoperative airway stenting (median, 5.5 days). Early (<30 days) complications occurred in 18 (41%) patients, mainly as transient airway and voice complaints, aspiration, and dysphagia. One (2%) patient died of myocardial infarction. Late morbidities were 2 failures occurring as bilateral recurrent nerve paralysis and restenosis requiring definitive tracheostomy. Patients had excellent or good anatomic (n = 42 [96%]), functional (n = 41 [93%]), or both types of long-lasting results, with no stenotic relapse. CONCLUSIONS: Partial cricoidectomy with primary thyrotracheal anastomosis can be applied in patients with postintubation stenosis extending up to 1 cm below the cords and measuring up to 6 cm in length with excellent-to-good definitive results. The association with a tracheoesophageal fistula does not contraindicate surgical repair.

LATE INTRACAVAL AND INTRACARDIAC LEIOMYOMATOSIS FOLLOWING HYSTERECTOMY FOR BENIGN MYOMAS TREATED BY SURGERY AND GnRH AGONIST
P. MORICE, A. CHAPELIER, P. DARTEVELLE, D. CASTAIGNE, C. LHOMME

Gynecol Oncol 2001 Nov; 83:422-423

BACKGROUND: The aim of this study was to report an exceptional case of a patient presenting with intracaval and intracardiac leiomyomatosis treated by combined surgical and medical treatment. CASE: A 48-year-old presented with intracaval and intracardiac leiomyomatosis (IL) discovered 6 years following a total hysterectomy with ovarian conservation for myomas. Surgical resection of the pelvic myomas and intracaval leiomyomatosis was performed during the same surgical procedure. Given the presence of a small tumor residuum in the pelvic cavity, postoperative medical treatment based on a gonadotropin-releasing hormone (GnRH) agonist was delivered for 1 year. The patient was followed-up using clinical examination and systematic CT scan. Ten months following the end of medical treatment, she is still in good health and the pelvic residuum has stabilized. CONCLUSIONS: Patients with pelvic tumor combined with IL could be treated using a one-stage surgical procedure. In cases of incomplete surgical resection, medical treatment based on GnRH agonist could be successfully delivered.

NONINVASIVE VENTILATION REDUCES MORTALITY IN ACUTE RESPIRATORY FAILURE FOLLOWING LUNG RESECTION
I. AURIANT, A. JALLOT, P. HERVE, J. CERRINA, F. LE ROY LADURIE, J. L. FOURNIER, B. LESCOT, F. PARQUIN

Am. J. respir Crit Care Med. 2001;164:1231-1235

When treated with invasive endotracheal mechanical ventilation (ETMV), acute respiratory insufficiency after lung resection is fatal in up to 80% of cases. Noninvasive positive-pressure ventilation (NPPV) may reduce the need for ETMV, thereby improving survival. We conducted a randomized prospective trial to compare standard therapy with and without nasal-mask NPPV in patients with acute hypoxemic respiratory insufficiency after lung resection. The primary outcome variable was the need for ETMV and the secondary outcome variables were in-hospital and 120-d mortality rates, duration of stay in the intensive care unit, and duration of in-hospital stay. Twelve of the 24 patients (50%) randomly assigned to the no-NPPV group required ETMV, versus only five of the 24 patients (20.8%) in the NPPV group (p = 0.035). Nine patients in the no-NPPV group died (37.5%), and three (12.5 %) patients in the NPPV group died (p = 0.045). The other secondary outcomes were similar in the two groups. NPPV is safe and effective in reducing the need for ETMV and improving survival after lung resection.

SEROTONIN TRANSPORTER OVEREXPRESSION IS RESPONSIBLE FOR PULMONARY ARTERY SMOOTH MUSCLE HYPERPLASIE IN PRIMARY PULMONARY HYPERTENSION
S. EDDAHIBI, M. HUMBERT, E. FADEL, B. RAFFESTIN, M. DARMON, F. CAPRON, G. SIMONNEAU, P. DARTEVELLE, M. HAMON, S. ADNOT

The Journal of Clinical Investigation. 2001; 108:1141-1150

Hyperplasia of pulmonary artery smooth muscle cells (PA-SMCs) is a hallmark pathological feature of primary pulmonary hypertension (PPH). Here we found that PA-SMCs from patients with PPH grow faster than PA-SMCs from controls when stimulated by serotonin or serum and that these effects are due to increased expression of the serotonin transporter (5-HTT), which mediates internalization of indoleamine. In the presence of 5-HTT inhibitors, the growth stimulatory effects of serum and serotonin were markedly reduced and the difference between growth of PA-SMCs from patients and controls was no longer observed. As compared with controls, the expression of 5-HTT was increased in cultured PA-SMCs as well as in platelets and lungs from patients with PPH where it predominated in the media of thickened pulmonary arteries and in onion-bulb lesions. The L-allelic variant of the 5HTT gene promoter, which is associated with 5-HTT overexpression and increased PA-SMC growth, was present in homozygous form in 65% of patients but in only 27% of controls. We conclude that 5-HTT activity plays a key role in the pathogenesis of PA-SMC proliferation in PPH and that a 5HTT polymorphism confers susceptibility to PPH.

2.- ARTICLES DANS REVUES NATIONALES.

CHIRURGIE DE LA VEINE CAVE SUPERIEURE
A. CHAPELIER, C. ANGEL, E. FADEL, P. DARTEVELLE

Encyclopédie médico-Chirurgicale Techniques Chirurgicales - Thorax 42-185 Chirurgie Vasculaire 43-178;2001 14 p

THROMBUS INTRA-CARDIAQUE ET EMBOLIE PULMONAIRE
X. BERTHAUX, E. FADEL, J.Y. MARANDON

S.T.V. Sang Thrombose Vaisseaux 2001;1-13:68

COMPARAISON DU FORMOTEROL 12 µg DEUX FOIS PAR JOUR ET DU SALBUTAMOL A LA DEMANDE EN CAS D'ASTHME PERSISTANT MODERE
M. MOLIMARD, J. BOURCEREAU, V. LE GROS, L. BOURDEIX, F. LEYNADIER, P. DUROUX en association avec le Groupe d'Etude Français for-F-01

Respiratory Medicine 2001;95:64-70

POLYMORPHISME DU GENE DU TRANSPORTEUR DE LA SEROTINE ET HYPERTENSION ARTERIELLE PULMONAIRE : CONSEQUENCES FONCTIONNELLES SUR L'HYPERPLASIE DES CELLULES MUSCULAIRES LISSES VASCULAIRES.
S. EDDAHIBI, M. HUMBERT, E. FADEL, G. SIMONNEAU, O. SITBON, B. RAFFESTIN, M. HAMON, S. ADNOT

Revue des Maladies respiratoires 2001; 18, 1S1-1S13

3.- PRESENTATIONS DANS DES CONGRES INTERNATIONAUX

Invited Lecture I: P. DARTEVELLE
ANTERIOR CERVICAL APPROACH FOR APICAL LUNG CANCER

11th World Congress The World Society of Cardio-Thoracic Surgeons- Sao Paulo (Brazil) August 12-15,2001

Invited Lecture II: P. DARTEVELLE
RESULTS OF CARINAL RESECTION FOR LUNG CANCER

11th World Congress The World Society of Cardio-Thoracic Surgeons- Sao Paulo (Brazil) August 12-15,2001

Invited Lecture IV: P. DARTEVELLE
EVALUATION AND OUTCOME OF DIFFERENT SURGICAL TECHNIQUES FOR POST-ENTUBATION TRACHEOESOPHAGEAL FISTULAS

11th World Congress The World Society of Cardio-Thoracic Surgeons- Sao Paulo (Brazil) August 12-15,2001

LUNG TRANSPLANTATION AND THROMBOENDARTERECTOMY
P. DARTEVELLE

Societa Italiana di Cardiologia. Roma 20 Marzo 2001

ROLE OF THROMBOTIC FACTORS IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
E. FADEL

3ème Journée Groupe de Recherche Maladies Vasculaires Pulmonaires UPRES EA 2705 Paris 6 Avril 2001

PULMONARY THROMBOENDARTERECTOMY : THE UNIVERSITY PARIS-SUD EXPERIENCE
P. DARTEVELLE

3ème Journée Groupe de Recherche Maladies Vasculaires Pulmonaires UPRES EA 2705 Paris 6 Avril 2001

LUNG REPERFUSION INJURY AFTER THROMBOENDARTERECTOMY
F. PARQUIN

3ème Journée Groupe de Recherche Maladies Vasculaires Pulmonaires UPRES EA 2705 Paris 6 Avril 2001

THROMBOENDARTERECTOMY IN POST-EMBOLIC HYPERTENSION : INDICATIONS AND RESULTS
P. DARTEVELLE

International meeting "Venous Thrombosis and Pulmonary Embolis : What has Changed ? Milan 20 April 2001

MANAGEMENT OF TUMORS INVOLVING THE SUPERIOR VENA CAVA
P. DARTEVELLE

Annual Meeting A.A.T.S. General Thoracic Surgery Symposium. San Diego May 6-9, 2001

RESTORATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE FUNCTION ONE MONTH AFTER REVASCULARIZATION OF CHRONICALLY OBSTRUCTED PULMONARY ARTERY.
E. FADEL, S. EDDAHIBI, GM. MAZMANIAN, B. BAUDET, R. MICHEL, P. DARTEVELLE, P. HERVE