(voir aussi 2004 2002 2001 2000 1999 1998 1997 1996 1995)
1.- ARTICLES DANS REVUES INTERNATIONALES
2.- ARTICLES DANS REVUES NATIONALES
3.- PRESENTATIONS DANS DES CONGRES INTERNATIONAUX
4.-PRESENTATIONS DANS DES CONGRES NATIONAUX
1.- ARTICLES DANS REVUES INTERNATIONALES
An extreme consequence of splenectomy in dehydrated hereditary stomatocytosis : gradual thrombo embolic pulmonary hypertension and heart lung transplantation
Jais X, Till SJ, Cynober T, Ioos V, Garcia G, Tchernia G,
Dartevelle P, Simonneau G, Delaunay J; Humbert M
Hemoglobin. 2003 Aug; 27(3):139-47
Dehydrated hereditary stomatocytosis (DHS) belongs to the heterogeneous class of hemolytic anemias with leaky red cell membranes. Splenectomy is a highly deleterious treatment, because it favors, with virtually no exception, the occurrence of thromboembolic disease. We describe here the extreme case of a patient with DHS and an associated sickle cell trait. Splenectomy was carried out due to a splenic infarction that occurred during an airplane journey. About 12 years later, the patient noticed an exertional dyspnea, which gradually worsened to such a degree that she became severely incapacitated within 5 years. Eventually, the patient developed a cor pulmonale associated with chronic thromboembolic pulmonary hypertension (CTEPH) and successfully underwent a heart-lung transplant operation. This case ranks as one of the most severe examples ever recorded of the effect that splenectomy may have in DHS patients. Nonetheless, it represents the first case to receive a heart-lung transplant.
Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease
Eddahibi S, Chaouat A, Morrell N, Fadel E, Fuhrman C, Bugnet AS,
Dartevelle P, Housset B, Hamon M, Weitzenblum E, Adnot S
Circulation. 2003 Oct 14;108(15):1839-44.Epub 2003 oct 06
BACKGROUND: The serotonin transporter (5-HTT) is involved in the pulmonary artery smooth muscle hyperplasia that leads to pulmonary hypertension (PH). Because hypoxia and 5-HTT gene polymorphism control 5-HTT expression, we examined 5-HTT gene polymorphism and PH in hypoxemic patients with advanced chronic obstructive pulmonary disease (COPD). METHODS AND RESULTS: In 103 patients with COPD recruited in France (n=67) and the UK (n=36), we determined 5-HTT gene polymorphism and pulmonary artery pressure (PAP) measured during right heart catheterization (France) or Doppler echocardiography (UK). Ninety-eight subjects from the 2 countries served as control subjects. The distribution of 5-HTT gene polymorphism did not differ between patients and control subjects. In patients carrying the LL genotype, which is associated with higher levels of 5-HTT expression in pulmonary artery smooth muscle cells than the LS and SS genotypes, PH was more severe than in LS or SS patients. Mean PAP values in patients from France with the LL, LS, and SS genotypes were 34+/-3, 23+/-1, and 22+/-2 mm Hg (mean+/-SEM), respectively (P<0.01). Corresponding systolic PAP values in the UK were 40+/-3, 28+/-3, and 24+/-3 mm Hg, respectively (P<0.01). Compared with control subjects, platelet 5-HTT protein was increased in COPD patients in proportion to the hypoxemia level, and strong 5-HTT immunostaining was observed in remodeled pulmonary arteries from COPD patients. CONCLUSIONS: 5-HTT gene polymorphism appears to determine the severity of PH in hypoxemic patients with COPD. Because PH is an important prognostic factor in this disease, recognition of patients at risk for PH should be helpful in managing COPD.
Analysis of CD4+CD25+ cell population in the thymus from myasthenia gravis patients
Balandina A, Saoudi A, Dartevelle P, Berrih-Aknin S
Ann NY Acad Sci. 2003 Sep;998:275-7
The present study is aimed at exploring the regulatory CD4(+)CD25(+) T cells in the thymus from myasthenia gravis (MG) patients. In early-onset MG, the thymus is hyperplastic and contains autoreactive activated T cells. Preliminary studies indicate that these CD4(+)CD25(+) cells include activated autoreactive T cells. Studies to characterize the phenotype and suppressive capacity of these cells will be discussed.
Heme oxygenase inhibits human airway smooth muscle proliferation via bilirubin-dependent modulation of ERK 1/2 phosphorylation
Taille C, Almolki A, Benhamed M, Zedda C, Meget J, Berger P,
Leseche G, Fadel E,Yamaguchi T, Marthan R, Aubier M, Boczkoski J
J Biol Chem. 2003 Jul 18;278(29):27160-8.Epub 2003 Apr 10
The aim of this study was to investigate whether the heme oxygenase (HO) pathway could modulate proliferation of airway smooth muscle (ASM) and the mechanism(s) involved in this phenomenon. In cultured human ASM cells, 10% fetal calf serum or 50 ng/ml platelet-derived growth factor AB induced cell proliferation, extracellular and intracellular reactive oxygen species (ROS) production and ERK1/2 phosphorylation. Pharmacological HO-1 induction (by 10 microm hemin or by 20 microm cobalt-protoporphyrin) and HO inhibition (by 25 microm tin-protoporphyrin or by an antisense oligonucleotide), respectively, reduced and enhanced significantly both cell proliferation and ROS production. Neither the carbon monoxide scavenger myoglobin (5-20 microm) nor the guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one could reverse ASM proliferation induced by tin-protoporphyrin, making a role of the CO-cGMP pathway in HO-modulated proliferation unlikely. By contrast, bilirubin (1 microm) and the antioxidant N-acetyl-cysteine (1 mm) significantly reduced mitogen-induced cell proliferation, ROS production, and ERK1/2 phosphorylation. Furthermore, both bilirubin and N-acetyl-cysteine and the ERK1/2 inhibitor PD98059 significantly reversed the effects of HO inhibition on ASM proliferation. These results could be relevant to ASM alterations observed in asthma because activation of the HO pathway prevented the increase in bronchial smooth muscle area induced by repeated ovalbumin challenge in immunized guinea pigs, whereas inhibition of HO had the opposite effect. In conclusion, this study provides evidence for an antiproliferative effect of the HO pathway in ASM in vitro and in vivo through a bilirubin-mediated redox modulation of phosphorylation of ERK1/2.
Monocyte chemotactic protein-1 (MCP-1) synthesis and function in pulmonary artery smooth muscle cells (PA-SMCs) from patients with idiopathic pulmonary hypertension (IPH)
Sanchez O, Fadel E, Humbert M, Dartevelle P, Simonneau G, Hamon M, Adnot S, Eddahibi S
European respiratory journal (in press)
Anterior cervicothoracic approach to the superior sulcus for radical resection of lung tumor invading the thoracic inlet
Philippe Dartevelle and Sacha Mussot
Operative Techniques in Thoracic and Cardiovascular Surgery, Vol 8, No 2 (May), 2003: pp86-93 2003
: A comparative Atlas Saunders editor.
Anterior approach to the superior sulcus lesions
Dartevelle P, Mussot S
6th Edition of General Thoracic Surgery. Shields sept 2003 In
press
Neurogenic intrathoracic tumors
Seguin A, Mussot S, Fadel E, Chapelier A, Dartevelle P
The Annals of Thoracic Surgery. (In press)
Anterior Approach to superior sulcus lesions
Dartevelle P, Mussot S
6th Edition of General Thoracic Surgery. Lippincott, Williams &
Wilkins Editor. (In Press)
Anterior Approach to pancoast tumors
Dartevelle P, Mussot S
7th Edition of Sabiston & Spencer's surgery of the Chest, Chapter
21. Elsevier Editor. (In press)
2.- ARTICLES DANS REVUES NATIONALES.
Traitement chirurgical de l'hypertension artérielle pulmonaire post embolique
Dartevelle P, Fadel E, Chapelier A, Mussot S, Cerrina J, Leroy
Ladurie F, Le Houerou D, Humbert M, Sitbon O, Parent F, Simonneau
G
Rev. Pneumol. Clin., 2004, 60, 2-124-134
syndrome cave superieur
De Perrot M, Dartevelle P
Elsevier. Traité Angéiologie, Encyclopédie
Médico Chirurgicale. In press
ACTUALITE DE L'HYPERTENSION ARTERIELLE PULMONAIRE
D.Montani, O. Sitbon, E.Fadel, P.Dartevelle, H.Nunes, D.Lebrec et
al
EMC-Pneumologie 2004 -Volume 1 Numéro 2 - pp 46-48
Indications et modalités de l'embolectomie mécanique ou chirurgicale
E.Fadel
Réalités cardiologiques.N° 193 - janvier 2004
Evolutions thérapeutiques dans l'EP grave.
E.Fadel
Réalités cardiologiques N° 193 - janvier 2004
PRISE EN CHARGE DU CŒUR PULMONAIRE CHRONIQUE POST EMBOLIQUE : UNE COOPERATION MEDICO CHIRURGICALE
P.Dartevelle P, Chapelier A, Fadel E, Mussot S, Cerrina J, Leroy ladurie F, Parquin F, Le Houerou D, Humbert M, Sitbon O, Simonneau G
Thrombose sous la direction de Christophe Leroyer Edition Margaux Orange 2004 pp27-41
3- PRESENTATIONS DANS DES CONGRES INTERNATIONAUX
carcinome bronchique non a petites cellules
Nourredine Gharbi. Première Rencontre Internationale d'Oncologie du Littoral. Marrakech 25-26/01/03
le point sur l'endoscopie interventionnelle
Nourredine Gharbi. Première Rencontre Internationale d'Oncologie du Littoral. Marrakech 25-26/01/03
traitement chirurgical de l'hypertension artérielle pulmonaire post embolique
Philippe Dartevelle. Sur invitation
Xème Congrès Maghrébien et XVIIIème Congrès Marocain des Maladies Respiratoires. Société Marocaine des Maladies Respiratoires Rabat 14-17/03/2003
Cas Cliniques interactifs d'endoscopie interventionnelle : ce qu'il faut faire, ce qu'il ne faut pas faire
Nourredine Gharbi. VI ème Journée de Formation Médicale Continue (AMPM) et 1ère Journée de Formation Médicale Continue (AFMAPATH). Marrakech 11-12/04/2003
video-assisted Pulmonary endarterectomy in postembolic pulmonary hypertension
Philippe Dartevelle sur invitation
Maine Medical Center-Department of Surgery. Portland-Maine 9/05/2003
Surgery for T3-T4
Elie Fadel sur invitation
Maine Medical Center. Department of Surgery. Portland-Maine 9/05/2003
Regression of post obstructive vasculopathy after revascularization of chronically obstructed pulmonary artery
Elie Fadel
83rd Annual Meeting of American Association for Thoracic Surgery. Boston. 3/04-9/05/03
Philippe Dartevelle
The European School for Cardio-Thoracic Surgery. Bergamo. 13/05/2003
polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive lung disease.
Elie Fadel
99th International Conference of the American Thoracic Society. Seattle-Washington. 16-21/05/03
perioperative management strategies in lung and heart-lung transplantation
Philippe Dartevelle,Walter Klepetko, Elbert P. Trulock. 3rd world Symposium on Pulmonary Arterial Hypertension. Venise 25/6/03
surgical techniques in lung and heart-lung transplantation
Philippe Dartevelle,Walter Klepetko. 3rd world Symposium on Pulmonary Arterial Hypertension. Venise 25/6/03
Surgical technique in thromboendarterectomy
Stuart W. Jamieson, E Meyer, Philippe Dartevelle,Walter Klepetko. 3rd world Symposium on Pulmonary Arterial Hypertension. Venise 25/6/03
surgery of post embolic pulmonary hypertension
Philippe Dartevelle. Sur invitation
17th Asia Pacific Congress on Disease of the Chest. College of Chest Physicians. Istanbul 28-31/08/03
new surgical approach-the video assisted pulmonary endarterectomy
Philippe Dartevelle. Sur invitation
"Update on Chronic Thromboembolic Pulmonary Hypertension". European Respiratory Society. Vienne 27-29/09/2003
surgical options in chronic pulmonary embolism
Lecture by Philippe Dartevelle
7th Annual Meeting of the Arab Thoracic Association. Beyrouth 9-12/10/03
the role of the surgeon in acute PE
Philippe Dartevelle
7th Annual Meeting of the Arab Thoracic Association. Beyrouth 9-12/10/03
the role of surgery in the T3 and T4 tumors
Philippe Dartevelle
7th Annual Meeting of the Arab Thoracic Association. Beyrouth 9-12/10/03
lung volume reduction surgery
Philippe Dartevelle
7th Annual Meeting of the Arab Thoracic Association. Beyrouth 9-12/10/03
surgical approach to pulmonary hypertension
Philippe Dartevelle. Sur invitation
Meeting on "An Integrated Approach to Pulmonary Diseases". Milan 6-8/11/2003
surgical approach to tumors involving the superior vena cava
Philippe Dartevelle. Sur invitation
Lecture for the Congress "An Integrated Approach to Pulmonary Diseases". Milan 6-8/11/2003
surgery for pulmonary hypertension
Lecture by Philippe Dartevelle. Sur invitation
The Eight Congress on Cardio Thoracic Surgery of the Societé Belge de Chirurgie Cardio Thoracique. Bruxelles 15.11/03
transcervical approach for resecting tumors located in the thoracic inlet
Lecture by Philippe Dartevelle. Sur invitation
The 56th Annual Meeting of the Japanese Association for Thoracic Surgery. Tokyo 16-22/11/2003
Meet the expert : pulmonary endarterectomy in post embolic pulmonary hypertension
Philippe Dartevelle. Sur invitation
The 56th Annual Meeting of the Japanese Association for Thoracic Surgery. Tokyo 16-22/11/2003
4.-PRESENTATIONS CONGRES NATIONAUX
La thoracoscopie medicale en 2003
Nourredine Gharbi
7ème Congrès de Pneumologie de Pneumologie. Nice 31/01-3/02/2003
Endoscopie et bronchopathie chronique obstructive
Nourredine Gharbi
7ème Congrès de Pneumologie de Pneumologie. Nice 31/01-3/02/2003
Endoscopie interventionnelle
Nourredine Gharbi
7ème Congrès de Pneumologie de Pneumologie. Nice 31/01-3/02/2003
Nouvelles technologies et patients
Philippe Dartevelle MEDEC Paris 12/3/2003 20-22/03/2003
Traitement chirurgical des sténoses trachéales : préparation et technique
Philippe Dartevelle 4èmes Rencontres Aquitaines. Biarritz 21/03/2003
Les tumeurs de la trachee
Philippe Dartevelle 4èmes Rencontres Aquitaines. Biarritz 21/03/2003
Les remplacements de la trachee
Philippe Dartevelle 4èmes Rencontres Aquitaines. Biarritz 21/03/2003
Indications et résultats de la transplantation pulmonaire et cardio pulmonaire
Philippe Dartevelle CHU Bicètre 26/03/03
Depistage individuel du cancer bronchique
Nourredine Gharbi. Groupe d'Endoscopie de Langue Française. Nimes 19-20/09/2003
Approche chirurgicale de hypertension artérielle pulmonaire post embolique : indications, suivi, pronostic
Philippe Dartevelle Société de Pathologie Thoracique du Nord & Association des Pneumologues Région Nord-Pas de Calais. Lille18/10/03
L'hypertension artérielle pulmonaire post embolique : avancées récentes
Philippe Dartevelle Strasbourg 4/12/03
Diplôme d'Université de Médecine d'urgence.
Elie Fadel. UFR Médicale Université Paris-Sud. Hôpital Bicètre janvier 2003
Tumeurs de la jonction cervico thoracique
Diplôme d'Université de Carcinologie Cervico Faciale. UFR Médicale Université Paris Sud.
Philippe Dartevelle. Institut Gustave Roussy-Villejuif 24/1/2003
Thrombo endartériectomie pulmonaire
Philippe Dartevelle. Amicale des Cardiologues des Yvelines. Ville d'Avray 4/2/2003
Critères d'acceptation du greffon
Philippe Dartevelle. Hôpital Saint Louis 4/2/2003
Traitement des goîtres endo thoraciques
Elie Fadel. Journée de Pathologie Thoracique 2003. ccml 28/03/2003
Staging ganglionnaire du cancer bronchopulmonaire : indications de la mediastinoscopie
Elie Fadel. Journée de Pathologie Thoracique 2003. CCML 28/03/2003
Résultats de la transplantation pulmonaire
Alain Chapelier. Journée de Pathologie Thoracique 2003. CCML 28/03/2003
Présentations cliniques des mediastinites fibreuses
Sacha Mussot. Journée de Pathologie Thoracique 2003. CCML 28/03/2003
Traitement chirurgical des médiastinites fibreuses
Philippe Dartevelle. Journée de Pathologie Thoracique 2003. CCML 28/03/2003
Goitres endothoraciques. histoire naturelle et complications
Nourredine Gharbi. Journée de Pathologie Thoracique 2003. CCML 28/03/
Staging ganglionnaire du cancer broncho pulmonaire
Nourredine Gharbi. Journée de Pathologie Thoracique 2003. CCML 28/03/
Tumeurs du poumon primitives et secondaires
Philippe Dartevelle. UFR Médicale Université Paris Sud-CHU Bicètre 25/04/2003
Greffe pulmonaire et cardio pulmonaire
Philippe Dartevelle . Etablissement français des Greffes. Paris 12/05/2003
L'endarteriectomie pulmonaire pour hypertension postembolique
Philippe Dartevelle. Service de Cardiologie-Hôpital Cochin. Paris 3/10/2003
Coeur pulmonaire chronique post embolique. la thrombo endartériectomie pulmonaire
Philippe Dartevelle. Service Pneumologie- Hôpital Antoine Béclère. Clamart 27/11/2003
Critères de gravité d'un traumatisme du thorax. Quel bilan réaliser devant un traumatisme du thorax ?
Elie Fadel. Séminaire des IMG. Hôpital Bicètre. Novembre 2003
76- THESES ET D.E.A. :
Viabilité de l'endothélium des artères pulmonaires après ischémie chronique-reperfusion Edouard Sage. Année 2002-2003
Elie Fadel. Directeur de DEA de Biologie et Physiologie de la Circulation et de la Respiration
Régression des lésions d'hypertension artérielle pulmonaires induites par la perfusion du poumon à partir de l'aorte chez le porc. Olaf mercier 2003-2004
Elie Fadel. Directeur de DEA de Biologie et Physiologie de la Circulation et de la Respiration