(voir aussi 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995)
PUBLICATIONS DANS DES REVUES INTERNATIONALES
PUBLICATIONS DANS DES REVUES NATIONALES
PRESENTATIONS DANS DES CONGRES NATIONAUX
PRESENTATIONS DANS DES CONGRES INTERNATIONAUX
PUBLICATIONS DANS DES REVUES INTERNATIONALES
Functional defect of regulatory CD4(+)CD25+T
cells in the thymus of patients with autoimmune myasthenia gravis
Balandina A., Lecart S., Dartevelle P., Saoudi A., Berrih-Aknin
S.
Blood 2005 Jan 15 ; 105(2) : 735-41 - Epub 2004 Sep 28
The present study is aimed at exploring the regulatory CD4(+)CD25(+) T cells in the thymus from myasthenia gravis (MG) patients. In early-onset MG, the thymus is hyperplastic and contains autoreactive activated T cells. Preliminary studies indicate that these CD4(+)CD25(+) cells include activated autoreactive T cells. Studies to characterize the phenotype and suppressive capacity of these cells will be discussed.
Graft ischemic time and outcome of lung
transplantation: a multicenter analysis
Thabut G., Mal H., Cerrina J., Dartevelle P., Dromer C., Velly JF.,
Stern M., Loirat P., Leseche G., Bertocchi M., Mornex JF., Haloun A.,
Despins P., Pison C., Blin D., Reynaud-Gaubert M.
Am J Respir Crit Care Med 2005 Apr 1: 171(7): 786-91 - Epub 2005 Jan 21
RATIONALE: The effect of graft ischemic time on early graft function and long-term survival of patients who underwent lung transplantation remains controversial. Consequently, graft ischemic time has not been incorporated in the decision-making process at the time of graft acceptance. OBJECTIVES: To investigate the relationship between graft ischemic time and (1) early graft function and (2) long-term survival after lung transplantation. MEASUREMENTS AND MAIN RESULTS: The data from 752 patients who underwent single lung transplantation (n = 258), bilateral lung transplantation (n = 247), and heart-lung transplantation (n = 247) in seven French transplantation centers during a 12-year period were reviewed. Independent data quality control was done to ensure the quality of the collected variables. Mean graft ischemic time was 245.8 +/- 96.4 minutes (range 50-660). After adjustment on 11 potential confounders, graft ischemic time was associated with the recipient Pa(O2)/FI(O2) ratio recorded within the first 6 hours and with long-term survival in patients undergoing single or double lung transplantation but not in patients undergoing heart-lung transplantation. The relationship between graft ischemic time and survival appears to be of cubic form with a cutoff value of 330 minutes. These results were unaffected by the preservation fluid employed. CONCLUSIONS: The results of this large cohort of patients suggest a close relationship between graft ischemic time and both early gas exchange and long-term survival after single and double lung transplantation. Such relationship was not found in patients undergoing heart-lung transplantation. The expected graft ischemic time should be incorporated in the decision-making process at the time of graft acceptance.
Para-ganglioma with ganglio-neuromatous
component located in the posterior mediastinum
De Montpreville Vt, Mussot S, Gharbi N, Dartevelle P, Dulmet
E.
Ann Diagn Pathol. 2005 Apr; 9(2):110-4
A 4-cm paravertebral mediastinal tumor was resected in a 70-year-old male patient treated for hypertension. The tumor displayed both paraganglioma and ganglioneuroma areas that were in equal proportion and often merged one into the other. Paraganglioma areas contained synaptophysin and chromogranin-positive chief cells and PS100-positive sustentacular cells. Ganglioneuroma areas contained neurofilament-positive mature ganglion cells and PS100-positive Schwann cells. Such pheochromocytoma-ganglioneuroma has not been previously reported in the mediastinum and appears as the adrenal and aorticosympathetic counterpart of gangliocytic paraganglioma described in other anatomic sites.
Influence of donor characteristics on outcome after lung
transplantation: a multicenter study.
Thabut G, Mal H, Cerrina J, Dartevelle P, Dromer C, Velly JF, Stern
M, Loirat P, Bertocchi M, Mornex JF, Haloun A, Despins P, Pison C,
Blin D, Simonneau G, Reynaud-Gaubert M.
J Heart Lung Transplant. 2005 Sep;24(9):1347-53
BACKGROUND: The liberalization of lung-donor criteria and the use of marginal donors have been advocated to face the current shortage of donors in lung transplantation. However, the impact of donor characteristics on the outcome of lung transplantation is still largely unknown. We aimed to determine, on a large cohort of patients, the effect of donors characteristics on short- and long-term outcome of lung transplantation METHODS: Between 1988 and 1998, a total of 785 adult patients underwent single-lung transplantation (n = 270), bilateral-lung transplantation (n = 251), and heart-lung transplantation (n = 264) in 7 centers in France. We constructed several multivariate models to assess the relationship between donor characteristics and early gas exchange, duration of mechanical ventilation, and long-term survival after lung transplantation. RESULTS: Among donor characteristics, donor gas exchange before harvest was found to be significantly associated with recipient early gas exchange, duration of mechanical ventilation, and long-term survival after adjustment for potential confounding variables. Moreover, nonlinear modeling showed a steep increase in the relative risk of death when donor PaO2/FiO2 before harvest was below 350 (hazard ratio 1.43; 95% confidence interval 1.10-1.85; p = 0.01). Donor and recipient sex mismatch were also found to be significantly associated with long-term survival. CONCLUSIONS: Although liberalization of lung-donor criteria may be considered to overcome the shortage of lung donors, our data suggest that the violation of the gas-exchange criterion should be avoided.
Resection of locally advanced (T4) non-small
cell lung cancer with cardio-pulmonary bypass.
De Perrot M, Fadel E, Mussot S, De Palma A, Chapelier A, Dartevelle
P.
Ann Thorac Surg. 2005 May;79(5):1691-6; Discussion 1697.
BACKGROUND: Resection of T4 non-small cell lung cancer (NSCLC) on cardiopulmonary bypass (CPB) has rarely been reported in the literature. Hence, we have reviewed our experience in the role of CPB for the surgical treatment of locally advanced NSCLC. METHODS: All patients undergoing lung resection for bronchogenic carcinoma on CPB in our institution between January 1998 and June 2004 were reviewed. RESULTS: Seven patients underwent lung resections on CPB for bronchogenic carcinoma during the study period. Cardiopulmonary bypass was performed for tumors invading the subclavian artery down to the aortic arch (n = 2), the descending aorta (n = 1), or the origin of the left pulmonary artery with the left atrium (n = 2). All patients were discharged home after 9 to 21 days (median, 15 days). In the long term, 2 patients are alive without recurrence 17 and 25 months after their operations, and 3 are alive with recurrence 8, 13, and 54 months postoperatively. Two additional patients required CPB while undergoing carinal resection for difficulty ventilating the left lung. Both patients had a difficult postoperative course, but were eventually discharged from hospital. One patient died without recurrence 6 months later, and the other is alive without recurrence after 72 months. CONCLUSIONS: This study confirms the safety of CPB for NSCLC invading the great vessels and/or the left atrium in well-selected patients, and its utility when pulmonary edema develops during carinal resection. Further studies, however, are required to confirm long-term survival.
Guidelines on diagnosis and treatment of pulmonary arterial hypertension
Galie N., Torbicki A., Barst R., Dartevelle P., Haworth S., Higenbottam T., Olschewski H., Peacock A., Pietra G., Rubin LJ., Simonneau G, Grupo de trabajo sobre el diagnostico y tratamiento de la hypertension arterial pulmonary de la Sociedad Europea de Cardiologia
Rev Esp Cardiol 2005 May; 58(5): 523-66
Surgical treatment of solitary adrenal
metastasis from non-small cell lung cancer
O Mercier, E Fadel, M.D.; M De Perrot, S Mussot, F Stella, A
Chapelier, P Dartevelle,
J Thorac Cardiovasc Surg. 2005 Jul; 130: 136-40
BACKGROUND: Management of solitary adrenal metastasis from non-small cell lung cancer is still debated. Although classically considered incurable, various reports with small numbers of patients have shown that surgical treatment might improve long-term survival. The aim of this study was to review our experience and to identify factors that could affect survival. METHODS: From January 1989 through April 2003, 23 patients underwent complete resection of an isolated adrenal metastasis after surgical treatment of non-small cell lung cancer. There were 19 men and 4 women, with a mean age of 54 +/- 10 years. The diagnosis of adrenal metastasis was synchronous with the diagnosis of non-small cell lung cancer in 6 patients and metachronous in 17 patients. The median disease-free interval for patients with metachronous metastasis was 12.5 months (range, 4.5-60.1 months). RESULTS: The overall 5-year survival was 23.3%. Univariate and multivariate analysis demonstrated that a disease-free interval of greater than 6 months was an independent and significant predictor of increased survival in patients after adrenalectomy. All patients with a disease-free interval of less than 6 months died within 2 years of the operation. The 5-year survival was 38% after resection of an isolated adrenal metastasis that occurred more than 6 months after lung resection. Adjuvant therapy and pathologic staging of non-small cell lung cancer did not affect survival. CONCLUSIONS: Surgical resection of metachronous isolated adrenal metastasis with a disease-free interval of greater than 6 months can provide long-term survival in patients previously undergoing complete resection of the primary non-small cell lung cancer.
Splenectomy and chronic thromboembolic
pulmonary hypertension
Jais X., Ioos V., Jardim C., Sitbon o., Parent F., Hamid A., Fadel
E., Dartevelle P., Simonneau G., Humbert M.
Thorax 2005 Dec 60(12): 1031-4
– Epub 2005 Aug 5
BACKGROUND: An increased prevalence of splenectomy has been
reported in patients with idiopathic pulmonary arterial hypertension.
Examination of small pulmonary arteries from these subjects has
revealed multiple thrombotic lesions, suggesting that thrombosis may
contribute to this condition. Based on these findings, we
hypothesised that splenectomy could be a risk factor for chronic
thromboembolic pulmonary hypertension (CTEPH), a condition defined by
the absence of thrombus resolution after acute pulmonary embolism
that causes sustained obstruction of the pulmonary arteries and
subsequent pulmonary hypertension. METHODS: The medical history,
clinical characteristics, thrombotic risk factors and haemodynamics
of 257 patients referred for CTEPH between 1989 and 1999 were
reviewed. In a case-control study the prevalence of splenectomy in
patients with CTEPH was compared with that of patients evaluated
during the same period for idiopathic pulmonary hypertension (n=276)
or for lung transplantation in other chronic pulmonary conditions
(n=180). RESULTS: In patients with CTEPH, 8.6% (95% CI 5.2 to 12.0)
had a history of splenectomy compared with 2.5% (95% CI 0.7 to 4.4)
and 0.56% (95% CI 0 to 1.6) in cases of idiopathic pulmonary arterial
hypertension and other chronic pulmonary conditions, respectively
(p<0.01). CONCLUSION: Splenectomy may be a risk factor for chronic
thromboembolic pulmonary hypertension.
Tracheal compression caused by straight back
syndrome, chest wall deformity, and anterior spinal displacement
techniques for relief
Grillo HC., Wright CD., Dartevelle PG., Wain JC., Murakami S.
Ann Thorac Surg 2005 Dec; 80(6): 2057-62
BACKGROUND: Straight back syndrome and other causes of extreme narrowing of the space between sternal notch and vertebrae can cause critical tracheal obstruction. Additional points of compression may result from the brachiocephalic artery and from anterior vertebral displacement. METHODS: Individualized surgical maneuvers are necessary to correct all points of obstruction. Techniques include sternoplasty, sternal division, reimplantation of brachiocephalic artery, correction of severe pectus excavatum, and posterior wall tracheoplasty. RESULTS: Four patients were successfully treated by individualized techniques with complete long-term relief of critical tracheal obstruction. CONCLUSIONS: Severe tracheal compression caused by straight back syndrome and other causes of narrowed sternospinal channel is surgically correctable.
Serotonin transporter and receptors in various
forms of human pulmonary hypertension
Marcos E., Fadel E., Sanchez O., Humbert M., Dartevelle P., Simonneau
G., Hamon M., Adnot S., Eddahibi S.
Chest 2005 Dec; 128(6 suppl): 552S-553S
Smooth muscle cell
matrix metalloproteinases in idiopathic pulmonary arterial
hypertension.
Lepetit H, Eddahibi S, Fadel E, Frisdal E, Munaut C, Noel A,
Humbert M, Adnot S, D'Ortho MP, Lafuma C.
Eur Respir J. 2005 May;25(5):834-42.
Pulmonary arterial hypertension (PAH) results from persistent vasoconstriction, smooth muscle growth and extracellular matrix (ECM) remodelling of pulmonary arteries (PAs). Matrix metalloproteinases (MMPs) are matrix-degrading enzymes involved in ECM turnover, and in smooth muscle cell (SMC) and endothelial cell migration and proliferation. MMP expression and activity are increased in experimental PAH. Therefore, this study investigated whether similar changes occur in idiopathic PAH (IPAH; formerly known as primary pulmonary hypertension). Both in situ and in vitro studies were performed on PAs from patients undergoing lung transplantation for IPAH and from patients treated by lobectomy for localised lung cancer, who served as controls. In IPAH, MMP-tissue inhibitor of metalloproteinase (TIMP) imbalance was found in cultured PA-SMCs, with increased TIMP-1 and decreased MMP-3. MMP-2 activity was markedly elevated as a result of increases in both total MMP-2 and proportion of active MMP-2. In situ zymography and immunolocalisation showed that MMP-2 was associated with SMCs and elastic fibres, and also confirmed the MMP-3-TIMP-1 imbalance. In conclusion, the findings of this study were consistent with a role for the matrix metalloproteinase-tissue inhibitor of metalloproteinase system in pulmonary vascular remodelling in idiopathic pulmonary arterial hypertension. The matrix metalloproteinase-tissue inhibitor of metalloproteinase imbalance may lead to matrix accumulation, and increased matrix metalloproteinase-2 activity may contribute to smooth muscle cell migration and proliferation. Whether these abnormalities are potential therapeutic targets deserves further investigation.
Resection
of Popliteal Artery Aneurysm with End-to-End Anastomosis
Alsac JM., Fadel E, Fabre D, Mussot S, Maury JM, Dartevelle
P.
EJVES Extra, Volume 10, Issue 2, August 2005, Pages 41-44.
PUBLICATIONS DANS DES REVUES NATIONALES
Perspectives on pulmonary vascular diseases
Humbert M., Dartevelle P., Simonneau G.
Presse Med. 2005 Nov 5 ; 34(19 Pt 2) : 1413-5
Surgical treatment of chronic thromboembolic
pulmonary hypertension
Dartevelle P., Fadel E., Mussot S., Cerrina J., Leroy-Ladurie F.,
Lehouerou D., Parquin F., Paul JF., Musset D., Humbert M., Sitbon O.,
Parent F., Simonneau G.
Presse Med. 2005 Nov 5;34:1475-86
Chronic thromboembolic pulmonary hypertension is a condition that has long remained in the shadows, a kind of orphan disease, because of the lack of any curative treatment. The renewal of interest by pulmonary specialists, cardiologists and thoracic surgeon is due to the development over the past 20 years of major new treatments: lung transplantation, continuous prostacyclin infusion, and pulmonary endarterectomy, in chronological order. Most patients with postembolic pulmonary arterial hypertension (PEPAH) in a sufficiently proximal location can benefit from curative surgical treatment by bilateral endarterectomy of the pulmonary arteries. This complex surgery, performed under deep hypothermic circulatory arrest, clears out the pulmonary vascular bed down through its subsegmental branches and results in a frank reduction in pulmonary vascular resistance and normalization of cardiopulmonary function. It is a curative procedure with a perioperative mortality rate less than 7% and a definitive result, unlike pulmonary and cardiopulmonary transplantation, which have a postoperative mortality rate of 20% and a 5-year survival rate of 50%. It is difficult to recognize the postembolic nature of pulmonary hypertension because there is no known history of venous thrombosis or embolic phenomena in more than 50% of cases. Diagnosis is based on the presence of mismatched segmental defects in the radioisotopic ventilation-perfusion scanning. To be accessible to endarterectomy, lesions must involve the main, lobar, or segmental arteries. When conducted by experienced operators according to specific protocols, pulmonary (frontal and lateral views of each lung) and multislice CT angiography optimize assessment of the lesion site. When the pulmonary vascular resistance evaluated by catheterization is correlated with the anatomical obstruction visible on the images, pulmonary endarterectomy has a mortality rate below 4% and offers the patient a substantial chance to regain normal cardiorespiratory function. In cases of pulmonary arterial hypertension due to older embolisms, major arteriolitis occurs in the nonobstructed areas and aggravates the pulmonary hypertension, which may become suprasystemic. The endarterectomy mortality rate is then higher, and in specific cases justifies preoperative medical treatment. Pulmonary or cardiopulmonary transplantation is indicated in this disease only when the lesions are too distal and thus inaccessible to endarterectomy.
Tumeurs de
Pancoast-Tobias avec envahissement vertebral: Classification
anatomo-chirurgicale, technique d'exerese, résultats.
- Fadel E, Court C, Missenard G, Chapelier A, Mussot S,
Dartevelle P.
Rachis.2004 Juin ;16(2) :111-118.
PRESENTATIONS DANS DES CONGRES NATIONAUX
Au Carrefour de la Médecine et de la
Chirurgie : « Pleurésies
purulentes », « Pathologies non tumorales de la
trachée et des bronches », « Traumatismes
thoraciques ».
P. Dartevelle (président de session), M. Riquet, A. Colchen,
E. Fadel
9ème Congrès de Pneumologie de Langue
Française &endash; Lille &endash; 4-7 février
2005
Rôle du chirurgien dans la maladie
veineuse thrombo-embolique
P. Dartevelle
Congrès « Hypertension artérielle et
cœur droit &endash; Maladie thrombo-embolique
veineuse » - Ile de Ré &endash; 16-17 avril
2005
CPC post-embolique : Traitement
chirurgical
P. Dartevelle
3ème journée française de l’HTAP
&endash; Paris-Bercy &endash; 20-21 octobre 2005
Traumatismes
Thoraciques : au carrefour de la médecine et de la
chirurgie
9ème Congrès de Pneumologie de Langue
Française Lille 4-7 Février 2005
Mercier O, Fadel E,
Mussot S, Chapelier A, Dartevelle P.
Résultats du traitement chirurgical des métastases
surrénaliennes isolées du cancer
broncho-pulmonaire.
57ème Congrès de la Société Française de Chirurgie Thoracique et Cardio-Vasculaire Toulouse
de Latour B, Fadel E,
Droz JP, de Perrot M, Mussot S, Chapelier A, Dartevelle P.
Chirurgie des tumeurs germinales malignes du
médiastin.
58ème Congrès de la Société Française de Chirurgie Thoracique et Cardio-Vasculaire Paris
PRESENTATIONS DANS DES CONGRES INTERNATIONAUX
Long-term résults after carinal
resection for carcinoma : Does the benefit warrant the
risk ?
M. De Perrot, E. Fadel, O. Mercier, S. Mussot, A. Chapelier, P.
Dartevelle
AATS &endash; 85th annual meeting &endash; San Francisco U.S.A. &endash; April 10-13/2005
Thromboendarterectomy : technique and
outcome
P. Dartevelle
4th Tracleer International Scientific Advisory Board (INSAB) Meeting on Chronic Thromboembolic Pulmonary Hypertension &endash; Zurich &endash; 1-2 July 2005
Peer review University of Bologna
P. Dartevelle
Bologne &endash; 29-31 août 2005
Pulmonary Endarterectomy
P. Dartevelle
ESC Congress 2005 - Stockolm &endash; 3-7 septembre 2005
Extended resection for Lung Cancer
P. Dartevelle
Birmingham Review Course &endash; Birmingham &endash; UK &endash; 17 septembre 2005
Innovations techniques en chirurgie
thoracique
P. Dartevelle
Congrès Collège Marocain Interdisciplinaire du Cœur et des Vaisseaux &endash; Rabat &endash; 24/09/05
Le traitement chirurgical de
l’hypertension artérielle pulmonaire post-embolique
P. Dartevelle
Congrès Collège Marocain Interdisciplinaire du Cœur et des Vaisseaux &endash; Rabat &endash; 24/09/05
Various Surgical Procedures in Différent
Types of Pulmonary Hypertension
P. Dartevelle
III Conference on: Recent Insights and New Perspectives in Lung Transplantation &endash; Pavia &endash; October 6-8/2005
Indications, technical aspects and results of
pulmonary endarterectomy for post-embolic pulmonary hypertension
P. Dartevelle
VIII annual meeting of the pulmonary circulation working group Spanish society of cardiology - Alicante &endash; 11 novembre 2005
Ruolo della chirurgia nell’ipertensione
polmonare : Endoarterectomia versus Trapianto Polmonare
P. Dartevelle
Convegno Internazionale su Aspetti Innovativi Chirurgici nella Patologia Oncologica e Vascolare del Torace &endash; Firenze &endash; 18 novembre 2005
Systemic blood supply
to the lung in chronic obstruction of the pulmonary arteries before
and after reperfusion (30 minutes)
- Elie Fadel
100 th International Conference of The American Thoracic
Society; San Diego May 20-25, 2005
Surgical
Management of Primary Mediastinal Germ Cell Tumors
- Elie Fadel
Princess Margaret Hospital. Department of Genito-Urinary Oncology. Toronto-Canada. 19/8/05
Surgical treatment
of solitary adrenal metastasis from non&endash;small cell lung
cancer
- Elie Fadel
Toronto General Hospital. Department of Thoracic Surgery. Toronto-Canada. 29/7/05
One stage
approoach for retroperitoneal and mediastinal metastatic testicular
tumor resection.
- Elie Fadel
Princess Margaret Hospital. Department of Genito-Urinary Oncology. Toronto-Canada. 9/12/05
Interactions between
Serotonin Transporter and Type II Bone Morphogenic Protein
Marcos E, Dewachter L, Fadel E, Humbert M, Raffestin B, Adnot S,
Rodman D, Eddahibi S.
100 th International Conference of The American Thoracic Society; San Diego May 20-25, 2005
Contribution of
angiopoietin/Tie2 pathway to pulmonary artery smooth muscle
hyperplasia in idiopathic pulmonary hypertension
Dewachter L, Fadel E, Humbert M, Barlier-Mur AM, Adnot S,
Naeije R, Eddahibi S.
15th Annual congress of the European Respiratory Society Copenhagen : September 17-21, 2005
Diplôme d'université de carcinologie cervico-faciale - UFR Médicale de l'université Paris-Sud - Institut Gustave Roussy
Les tumeurs de la jonction cervico-thoracique
P. Dartevelle
Etudes Médicales Dcem2 - Université Paris Sud
Traumatismes thoraciques
P. Dartevelle
Diplôme d'Université de carcinologie cervico-faciale. UFR Médicale Université Paris Sud. Institut Gustave Roussy
Journée de formation scanner CCML
Le scanner dans le cœur-pulmonaire chronique post-embolique : L'attente du chirurgien, l’apport du scanner multi-barrettes.
P.Dartevelle
Dcem3. Université Paris Sud. Bicêtre
Cancer du poumon.
P.Dartevelle
Diplôme inter-universitaire de transplantation UFR Médicale de l’Université Paris-Sud
P. Dartevelle
Diplôme universitaire de chirurgie cervico-faciale Institut Gustave Roussy Université Paris-Sud
P. Dartevelle
Indications chirurgicales actuelles dans le CPC embolique
P. Dartevelle
Hôpital Henri Mondor &endash; 11 mars 2005
Chirurgie de la trachée &endash; Techniques et résultats
P. Dartevelle
7ème séminaire du Collège France-Nord &endash; Strasbourg &endash; 1-2 avril 2005
Abordagem anterior transcervical aos tumores do
apice toracico
Amarilio Macedo, Philippe G. Dartevelle
Cirurgia Toracica Geral &endash; Capitulo
34
Editora Atheneu &endash; Sao Paulo (Bresil) 2005
Anterior approach to superior sulcus
lesions
Ph Dartevelle &endash; S. Mussot
General thoracic Surgery &endash; 6e Edition
&endash; 2005 &endash; 587-601
Edited By Thomas W Shields - Lippincott, Williams & Wilkins
Editor.
Use of prosthetic grafts for replacement of the
superior vena cava
Paolo Macchiarini and Philippe Dartevelle
General Thoracic Surgery 6th Edition. &endash;
2005 &endash; 2572-2580
Edited By Thomas W Shields Ed. Lippincott Williams & Wilkins,
Philadelphia.
Anterior approach to Pancoast tumors
Dartevelle P, Mussot S
Surgery Of The Chest -Edition 2005 of Sabiston
& Spencer &endash; Chapter 21 &endash; 313-322
Elsevier Editor. (2005)