( voir aussi 2004 2003 2002 2001 2000 1999 1998, 1996 et 1995)
1.- PUBLICATIONS DANS DES REVUES INTERNATIONALES
Effects of various timings and concentrations of inhaled nitric
oxide in lung ischemia-reperfusion. The Paris-Sud University Lung
Transplantation Group.
Murakami S; Bacha EA; Mazmanian GM; Détruit H; Chapelier A;
Dartevelle P; Hervé P Am J Respir Crit Care Med, 1997 Aug,
156:2 Pt 1, 454-8
(abstract)
EXTENDED OPERATIONS FOR THE TREATMENT OF LUNG
CANCER. -
P.G. DARTEVELLE .Herbert Sloan Lecture - ANN THORAC SURG 1997; 63:
12-19
RADICAL RESECTION OF
RADIATION-INDUCED SARCOMA OF THE CHEST WALL : REPORT OF 15 CASES.
AR. CHAPELIER, EA BACHA, VT. DE MONTPREVILLE, EM. DULMET, M.
RIETJENS, A. MARGULIS, P. MACCHIARINI and P. DARTEVELLE .ANN THORAC
SURG. 1997; 63: 214-219 (Abstract)
ASPERGILLUS
OSTEOMYELITIS AFTER HEART-LUNG TRANSPLANTATION
J. TAILLANDIER, M. ALEMANI, J. CERRINA, F. LE ROY LADURIE and P.
DARTEVELLE. J. HEART LUNG TRANSPLANT 1997;16:436-438 (abstract)
TRACHEAL GROWTH AFTER
SLIDE TRACHEOPLASTY
P. MACCHIARINI, E. DULMET, V.DE MONTPREVILLE, GM. MAZMANIAN, A.
CHAPELIER, P. DARTEVELLE . J. THORACIC CARDIOVASC SURG. 1997;
113:558-566 (abstract)
INHALED NITRIC
OXIDE ATTENUATES REPERFUSION INJURY IN NON-HEARTBEATING-DONOR LUNG
TRANSPLANTATION
E. BACHA, H. SELLAK, S. MURAKAMI, GM. MAZMANIAN, H. DETRUIT, V. DE
MONTPREVILLE, AR. CHAPELIER, JM. LIBERT, PG. DARTEVELLE, P. HERVE for
the Paris-Sud University Lung Transplantation Group.
TRANSPLANTATION 1997; 63/10:1380-6
( abstract)
INHALED NITRIC OXIDE
AND PENTOXIFYLLINE IN RAT LUNG TRANSPLANTATION FROM NON-HEARTBEATING
DONORS
S. MURAKAMI, EA. BACHA, P. HERVE, H. DETRUIT, AR. CHAPELIER, PG.
DARTEVELLE, GM. MAZMANIAN, The Paris-Sud University Lung
Transplantation Group.
J. THORACIC CARDIOVASC SURGERY. 1997,113/5 : 821-829
(abstract)
PROGNOSTIC VALUE OF
PULMONARY HYPERTENSION IN PATIENTS WITH CHRONIC INTERSTITIAL LUNG
DISEASE REFERRED FOR LUNG AND HEART-LUNG TRANSPLANTATION
S. HARARI, G. SIMONNEAU, E. DE JULI, F. BRENOT, J. CERRINA, P.
COLOMBO, E. GRONDA, E. MICALLEF, F. PARENT, P. DARTEVELLE.
J. OF HEART AND LUNG TRANSPLANTATION . 1997;16:460-463
(abstract)
EX-VIVO LUNG MODEL OF PIG
TO HUMAN HYPERACUTE XENOGRAFT REJECTION.
P. MACCHIARINI, M. MAZMANIAN, R. ORIOL, V. MONTPREVILLE, E. DULMET,
D. RIEBEN, S. DOUBIN, JM. LIBERT, R. DAHA, P. DARTEVELLE.
J. THORAC CARDIOVASC SURG. 1997;114;3:315-325
(abstract)
CARINAL RESECTION FOR LUNG CANCER
P. DARTEVELLE, P. MACCHIARINI
JOURNAL OF JAPANESE CHEST SURGERY. 1997;11/7:890--898
2.- PUBLICATIONS DANS DES REVUES NATIONALES
TRAITEMENT CHIRURGICAL DE LA MALADIE
THROMBO-EMBOLIQUE PULMONAIRE CHRONIQUE
P. DARTEVELLE, E. FADEL, A. CHAPELIER, P. MACCHIARINI, J. CERRINA, F.
LEROY LADURIE, F. PARQUIN, F. SIMONNEAU, F. PARENT, M. HUMBERT, G.
SIMONNEAU
SANG THROMBOSE VAISSEAUX. 1997; 9: 241-250
INFECTIONS PULMONAIRES EN TRANSPLANTATION
D'ORGANES SOLIDE
F. PARQUIN, F. LE ROY LADURIE, J. CERRINA, P. DARTEVELLE
Pathologie Infectieuse en PNEUMOLOGIE (P. Léophonte, M.
Carré) Ed. Ellipses. 1997; 150-162
STENOSES TRACHEALES IATROGENES
A. CHAPELIER, P. DARTEVELLE
LE LIVRE DE L'INTERNE. PNEUMOLOGIE. Sergio Salmeron, Pierre Duroux,
Dominique Valeyre. Flammarion Médecine-Sciences. 1997; Chap.
18 : 219-224
TECHNIQUES CHIRURGICALES
E. FADEL, A.CHAPELIER, P. DARTEVELLE
LE LIVRE DE L'INTERNE. PNEUMOLOGIE. Sergio Salmeron, Pierre Duroux,
Dominique Valeyre. Flammarion Médecine-Sciences. 1997; Chap.
14:162-168
TRANSPLANTATIONS PULMONAIRES
F. LE ROY LADURIE, J. CERRINA, F. PARQUIN, A. CHAPELIER, P.
DARTEVELLE.
LE LIVRE DE L'INTERNE. PNEUMOLOGIE. Sergio Salmeron, Pierre Duroux,
Dominique Valeyre. Flammarion Médecine-Sciences. 1997; Chap.
70:789-794
COMPLICATIONS DES TRANSPLANTATIONS PULMONAIRES
F. LE ROY LDURIE, J. CERRINA, F. PARQUIN, A. CHAPELIER, P.
DARTEVELLE.
LE LIVRE DE L'INTERNE. PNEUMOLOGIE. Sergio Salmeron, Pierre Duroux,
Dominique Valeyre. Flammarion Médecine-Sciences. 1997; Chap.
71:795-803
TRANSPLANTATIONS PULMONAIRES ET
CARDIOPULMONAIRES
F. LE ROY LADURIE, P. DARTEVELLE
ENCYCLOPEDIE MEDICO-CHIRURGICALE (Elsevier Paris)
Cardiologie-Angéiiologie. 11-038-D-10, 1997, 9 p.
3.- PRESENTATION DANS DES CONGRES INTERNATIONAUX
LUNG BACTERIAL INFECTION : PREVENTION -
DONOR AND RECIPIENT PROPHILAXIS. THE PROBLEM IN LUNG AND HEART AND
LUNG TRANSPLANTATION.
J. CERRINA.
CONGRESS ON "PULMONARY INFECTIONS IN ORGAN TRANSPLANTATION" Ospedale
Niguarda Ca'Granda. MILAN 14-15 February 1997
LUNG BACTERIAL INFECTION : THE STAPHILOCOCCUS
AUREUS.
F. PARQUIN.
CONGRESS ON "PULMONARY INFECTIONS IN ORGAN TRANSPLANTATION" Ospedale
Niguarda Ca'Granda. MILAN 14-15 February 1997
INHALED NITRIC OXIDE ATTENUATES
ISCHEMIO-REPERFUSION INJURY AFTER NON-HEART-BEATING-DONOR LUNG
TRANSPLANTATION.
E.BACHA, S. MURAKAMI, P. MACCHIARINI, GM . MAZMANIAN, AR CHAPELIER,
P. HERVE, and PG. DARTEVELLE.
77th Annual Meeting - THE AMERICAN ASSOCIATION FOR THORACIC SURGERY -
Washington May 4-7, 1997
Invited Lecture : P. DARTEVELLE
RESULTS OF CARINAL RESECTION FOR LUNG CANCER.
14th ANNUAL MEETING OF THE JAPANESE ASSOCIATION FOR CHEST SURGERY.
KANAZAWA - 8-9 May 1997
Invited Lecture : P. DARTEVELLE
ANTERIOR TRANSCERVICAL THORACIC APPROACH FOR PANCOAST TUMORS
14th ANNUAL MEETING OF THE JAPANESE ASSOCIATION FOR CHEST SURGERY.
KANAZAWA - 8-9 May 1997
Invited Lecture : P. MACCHIARINI
LUNG XENOTRANSPLANTATION
GENERAL THORACIC BIOLOGY CLUB - AMERICAN ASSOCIATION FOR THORACIC
SURGERY - WASHINGTON 3 May 1997
ISOLATED PIG LUNGS PERFUSED WITH HUMAN BLOOD AS A
MODEL TO STUDY THE PIG TO HUMAN XENOTRANSPLANT REJECTION
P. MACCHIARINI, GM. MAZMANIAN, R. RIEBEN, P. DARTEVELLE, R. ORIOL
The 4th international Congress for XENOTRANSPLANTATION. NANTES
Septembre 7-11, 1997
SUBCLAVIAN ARTERY RESECTION AND RECONSTRUCTION FOR
THORACIC INLET CANCERS
E. FADEL, A.CHAPELIER, E. BACHA, P; MACCHIARINI and P.DARTEVELLE
23rd World Congress of THE INERNATIONAL SOCIETY FOR CARDIOVASCULAR
SURGERY. LONDON, Septembre 21-26, 1997
CERVICO-THORACIC ANTERIOR APPROACH FOR RESECTION
OF PANCOAST TUMORS
P. DARTEVELLE
11th Annual Meeting of the EUROPEAN ASSOCIATION FOR CARDIO-THORACIC
SURGERY - COPENHAGEN 28 Septembre-1 octobre 1997
ANTERIOR TRANSCEVICAL THORACIC APPROACH FOR
RESECTION OF THE THORACIC OUTLET FOR PRIMARY AND METASTATIC
TUMORS
P. DARTEVELLE
SOCIETA ITALIANA DI CHIRURGIA ONCOLOGICA Meeting on "Pathology of the
Cervicothoracic Junction" MILAN 14 Novembre 1997
Invited Lecture : P. DARTEVELLE
IL TRAPIANTO DI POLMONE : L'ESPERIENZA DEL MARIE LANNELONGUE DI
PARIGI
UNIVERSITA DEGLI STUDI DI MILANO - MILAN 15 November 1997
Invited Lecture : P. MACCHIARINI
EPIDEMIOLOGY OF LUNG DISEASES AND ITS IMPACT ON THORACIC SURGERY
MANAGEMENT COURSE IN CARDIO-THORACIC SURGERY - Palma de Mallorca,
23-25 November 1997
Invited Lecture : P. DARTEVELLE
SLEEVE PNEUMONECTOMY
International Symposium UP DATE ON TRACHEAL DISEASE. TREVISO. 4-5
Décembrer 1997
4.- PRESENTATION DANS DES CONGRES NATIONAUX
CHIRURGIE DES TUMEURS PRIMITIVES DE LA PAROI
THORACIQUE - EXPERIENCE DE L'HOPITAL MARIE LANNELONGUE
A. CHAPELIER
Réunion Annuelle du GROUPE THORAX - PRAGUE 24 JANVIER
1997
THROMBO-ENDARTERIECTOMIE PULMONAIRE - CHIRURGIE DU
COEUR PULMONAIRE CHRONIQUE POST-EMBOLIQUE
P. DARTEVELLE
Journées Présidentielles de la SOCIETE DE CHIRURGIE
THORACIQUE ET CARDIO VASCULAIRE DE LANGUE FRANCAISE - Paris 5 - 6
Juin 1997
5) THESES
THESE DE DOCTORAT DE SCIENCES DE LA VIE
Paolo MACCHIARINI : LA TRANSPLANTATION DE TRACHEE ET
TRACHEO-OESOPHAGIENNE. Université de Franche Comté.
Besançon le 2 Octobre 1997
THESE DE DOCTORAT DE SCIENCES DE LA VIE
Alain CHAPELIER : ISCHEMIE-REPERFUSION APRES TRANSPLANTATION.
PREVENTION PAR ACTION PHARMACOLOGIQUE ET THERAPIE GENIQUE.
Université de Franche Comté. Besançon le 10
Novembre 1997
THESE DE DOCTORAT EN MEDECINE
Christophe LANCELIN : PLAIES ET TRAUMATISMES DE L'AXE
LARYNGO-TRACHEAL ET DES BRONCHES. A PROPOS DE 27 OBSERVATIONS.
Université René Descartes. Faculté de
Médecine Necker-Enfants Malades. 7 Octobre 1997.
BACKGROUND: Surgical management of radiation-induced sarcoma of the chest wall remains difficult because of its impressive local aggressiveness. METHODS: Between 1987 and 1995, 15 patients (medianage, 58 years) underwent radical resection of radiation-induced sarcomaof the chest wall. This type of tumor was defined as a metachronous,histologically different neoplasm in the irradiated field of theoriginal tumor. Ten patients had a history of primary breast cancer and 5 patients, Hodgkin's disease. The median delivered radiation dose to the primary tumor area was 45 Gy, and the median interval between radiotherapy and diagnosis of sarcoma was 14 years. Seven tumors were located on the sternum, three on the lateral chest wall, and five in the thoracic outlet. Four total and three partial sternectomies, three lateral chest wall resections and five resections of tumors in the thoracic outlet (three first-rib resections) were performed. Seven patients required stabilization of the chest wall with prosthetic material. Soft tissue reconstruction was carried out with either muscle flaps and skin advancement in 9, musculocutaneous flaps in 4, or skin flaps alone in 2 patients. RESULTS: One patient died 3 months after total sternectomy of respiratory failure. Two patients (13.3%) had a local complication: sepsis after sternectomy in 1 and cutaneou necrosis in 1. Local recurrence occurred in 7 patients after a median interval of 10 months. Two of them died, and 4 underwent a repeat resection, 3 of whom are still alive. Four patients died of systemic recurrence. With a median follow-up of 30 months, overall 5-year survival and 5-year disease-free survival rates were 48% and 27%, respectively. CONCLUSION: Despite poor long-term disease-free survival, radical resection of radiation-induced sarcoma of the chest wall is justified on the basis of low postoperative morbidity and the lack of other available therapies.
OBJECTIVE: Our objective was to study lung hyperacute rejection in the pig-to-human xenotransplantation combination. METHODS: Pig lungs were harvested and continuously ventilated and perfused ex vivo, using a neonatal oxygenating system, with either xenogeneic unmodified human blood (n = 6) or autogeneic pig blood (n = 6). RESULTS: Autoperfused lungs displayed normal hemodynamics, oxygen extraction (arteriovenous oxygen difference), and histologic characteristics throughout the3-hour study period. By contrast, xenoperfused lungs displayed, within 30 minutes, severe pulmonary hypertension and abolishment of arteriovenous oxygen difference culminating in massive pulmonary edema, hemorrhage, and lung failure after 115 +/- 44.2 minutes of reperfusion. Within 30 minutes, the human blood showed a significant drop of anti-alpha Gal immunoglobulin M and G xenoreactive antibodies (enzyme-linked immunosorbent assay) and complement activity, consumption of clotting factors, and hemolysis; total circulating human immunoglobulins remained substantially normal. Histologically, lungs perfused with human blood were congestive and showed alveolar edema and hemorrhage and multiple fibrin and platelet thrombi obstructing the small pulmonary vessels (arterioles, capillaries, and venules) but not large (segmental or lobar) pulmonary vessels. On immunohistologic examination, deposits of human immunoglobulin M and complement (C1q and C3) proteins were observed on the alveolar capillaries. CONCLUSIONS: This pig-to-human xenograft model suggests that the pig lung perfused with human blood has an early and violent hyperacute rejection that results in irreversible pulmonary dysfunction and failure within approximately 150 minutes of reperfusion.
Experimental studies reveal that inhaled nitric oxide (NO) can prevent,worsen, or have no effect on lung injury in the setting of ischemia-reperfusion (I-R). We tested the hypothesis that these disparate effects could be related to differences in the timing of administration and/or concentration of inhaled NO during I-R. Isolated rat lungs were subjected to 1-h periods of ischemia followed by 1-h periods of blood reperfusion. We investigated the effects of NO (30 ppm) given during ischemia, NO (30 or 80 ppm) begun immediately at reperfusion, or NO (30 ppm) given 15 min after the beginning of reperfusion, on total pulmonary vascular resistance (PVR), the coefficient of filtration (Kfc), the lung wet/dry weight ratio (W/D) of lung tissue, and lung myeloperoxidase activity (MPO). A control group did not receive NO. NO given during ischemia had no effect on Kfc or MPO, but decreased PVR. NO (30 ppm) during reperfusion (early or delayed) decreased PVR, W/D, Kfc and MPO. NO at 80 ppm decreased PVR and MPO but not W/D or Kfc. In conclusion, NO at 30 ppm, given immediately or in a delayed fashion during reperfusion, attenuates I-R-induced lung injury. NO at 30 ppm given during ischemia or at 80 ppm during reperfusion is not protective.
BACKGROUND: The purpose of this study was to identify precise and reliable prognostic parameters in patients affected by serious chronic interstitial lung disease, who were undergoing screening for lung or heart-lung transplantation. METHODS: Hemodynamic and respiratory function parameters of 67 patients (43 with idiopathic pulmonary fibrosis, 18 with histiocytosis X, and 6 with lymphangioleiomyomatosis) undergoing clinical screening for lung transplantation. RESULTS: Statistical analysis showed that hemodynamic and respiratory function parameters in patients affected by histiocytosis X and idiopathic pulmonary fibrosis were not related to survival time. Moreover, the degree of pulmonary hypertension showed no correlation between respiratory function parameters in all the groups of diseases examined Patients affected with histiocytosis X, even with higher degrees of pulmonary hypertension, had a better survival rate (p < 0.0005) compared with patients with idiopathic pulmonary fibrosis. CONCLUSIONS: Hemodynamic and respiratory parameters obtained during the clinical screening for lung transplantation do not predict survival and cannot be used as prognostic indicators.
Aspergillus osteomyelitis is a severe complication of invasive aspergillosis. Fewer than 15 cases have been observed after solid organ transplantation. We describe a case of Aspergillus osteomyelitis of the ilium after heart-lung transplantation with favorable outcome after medical treatment.
BACKGROUND: Non-heartbeating-donor (NHBD) lung transplantation could help reduce the current organ shortage. Polymorphonuclear neutrophil (PMN) activation plays a pivotal role in ischemia-reperfusion injury (I-R), and can be inhibited by nitric oxide (NO). We hypothesized that inhaled NO might be beneficial in NHBD lung transplantation. METHODS: The effect of inhaled NO on PMNs was studied by measuring in vivo PMN lung sequestration (myeloperoxidase activity) and adhesion of recipient circulating PMNs to cultured pulmonary artery endothelial cells (PAECs) in vitro. Pigs were randomly assigned to an NO or a control group (n=9 each). In the NO group, cadavers and recipients were ventilated with oxygen and 30 parts per million of NO. After 3 hr of postmortem in situ warm ischemia and 2 hr of cold ischemia, left allotransplantation was performed. The right pulmonary artery was ligated, and hemodynamic and gas exchange data were recorded hourly for 9 hr. Recipient PMN adherence to tumor necrosis factor-alpha- and calcium ionophore-stimulated PAECs was measured before and after reperfusion, and lung PMN sequestration was determined after death. RESULTS: NO-treated animals exhibited lowered pulmonary vascular resistance (P<0.01), as well as improved oxygenation (P<0.01) and survival (P<0.05). Adhesion of PMNs to PAECs was inhibited in the NO group before (P<0.001) and after reperfusion (P<0.0001). Lung PMN sequestration was reduced by NO (P<0.05). CONCLUSIONS: Inhaled N attenuates I-R injury after NHBD lung transplantation. This is likely due to the prevention of I-R-induced pulmonary vasoconstriction and to the direct effect on peripheral blood PMN adhesion to endothelium, which results in reduced sequestration and tissue injury.
BACKGROUND: In non-heart-beating donor lung transplantation, postmortemwarm ischemia poses a special challenge. Inhaled nitric oxide and pentoxifylline have been shown to attenuate ischemia-reperfusion injury after lung transplantation. We hypothesized that concomitant administration of inhaled nitric oxide and pentoxifylline would result in a synergistic effect on ischemia-reperfusion lung injury. METHODS Lungs were harvested from non-heart-beating donors after 30 minutes of in situ warm ischemia, flushed, and stored for 2 hours at 4 degrees C before left lung transplantation in rats. Inhaled nitric oxide (30 ppm) was added during cadaver ventilation and reperfusion; pentoxifylline was given intravenously throughout reperfusion. The following groups were studied (n = 8 each): control, pentoxifylline, nitric oxide, and nitric oxide+pentoxifylline. Hemodynamic indices and arterial blood gases were obtained after ligation of the right pulmonary artery. Lung myeloperoxidase and wet/dry ratio were measured after death. RESULTS: All rats that did not receive nitric oxide died within 10 minutes after ligation. Inhaled nitric oxide significantly decreased pulmonary vascular resistance and improved recipient survival. Nitric oxide + pentoxifylline improved pulmonary vascular resistance, arterial oxygen tension, and survival even further and reduced lung myeloperoxidase as compared with the group that received nitric oxide only. Preservation solution flush time was significantly decreased in both groups receiving nitric oxide, suggesting that inhaled nitric oxide used during cadaver ventilation allows for a more even distribution of the preservation solution. CONCLUSIONS: We conclude that treatment with inhaled nitric oxide + pentoxifylline results in a synergistic protection from ischemia-reperfusion injury after non-heart-beating donor lung transplantation. This is likely the result of a dual action on the graft vasculature and neutrophil sequestration.
OBJECTIVE: Our goal was to investigate the effects of slide tracheoplasty on tracheal growth in newborn piglets. METHODS: Slide tracheoplasty was performed on normal trachea (n = 6) and a model of tracheal stenosis resembling that seen in infants (n = 6). After division of the trachea at its midportion between the second cartilaginous ring above and the right upper lobe takeoff below (around 23 rings), the proximal and distal segments were incised vertically on opposite anterior and posterior surfaces and reconstructed together. RESULTS: The reconstructed tracheas lengthened and their cross-sectional areas enlarged linearly at a rate of 0.94 cm per month and 1.55 mm2/kg, respectively, as the piglets grew over a 6-month period from 4.7 +/- 0.6 to 64.4 +/- 5.7 kg (+/- standard deviation). Growth was not different between the two studied groups. There was no narrowing or late restenosis. The mean anastomotic cross-sectional area was overall 1.63 +/- 0.28 times larger (range 1.2 to 2.7) than the cross-sectional area of the unreconstructed trachea. When the animals were put to death, all tracheal lumina were completely lined with normal respiratory epithelium and all layers were histologically intact; anastomotic trachealis muscles contracted less (p < 0.001) but relaxed similarly to those muscles lining normal tracheas. Tracheal blood supply was macroscopically and microscopically normal in both groups; however, newborn piglets had an almost twofold increased number of intramural capillary vessels as opposed to adult pigs (p < 0.001). CONCLUSIONS: Results suggest that slide tracheoplasty is not limited by the length of stenosis, provides a permanent enlargement of the cross-sectional airway diameter, does not compromise tracheal vascular supply, and does not impair tracheal growth as somatic growth continues.