CHAPITRES DE LIVRES sur invitations par Editeurs
ARTICLES ORIGINAUX DANS DES REVUES INTERNATIONALES
ARTICLES DANS DES REVUES NATIONALES.
CONFERENCES SUR INVITATION PAR UNIVERSITES ETRANGERES
PRESENTATIONS A DES CONGRES INTERNATIONAUX
PRESENTATION A DES CONGRES NATIONAUX
HABILITATION A DIRIGER DES RECHERCHES
CHAPITRES DE LIVRES sur invitations par Editeurs
RESECTION OF SUPERIOR SULCUS TUMORS
P. DARTEVELLE, P. MACCHIARINI
Master of Cardiothorac Surgery ed .by Larry R. Kaiser, Irving L.
Kron, Thomas L. Spray. (Lippincott - Raven Publishers
Philadelphia-New Yordk. 257-265. 1998
EXTENDED RESECTIONS FOR LUNG CANCER
P MACCHIARINI and P. DARTEVELLE
LUNG CANCER Second Edition By Jack A. Roth, James D. Cox, Waum Ki
Hong. ( Ed. Blackwell Science, Inc. Cambridge) Chapitre 8, 135-161.
1998
LUNG ISCHEMIA-REPERFUSION INJURY AFTER CHRONIC PULMONARY ARTERY
OCCLUSION
E. FADEL, G. MAZMANIAN, B. BAUDET, H. DETRUIT, V. de MONTPREVILLE, P.
DARTEVELLE and P. HERVE
20th European Conference on MICROCIRCULATION. (Ed. Patrick
H.Carpentier, Eric Vigaut, Jean Louis Guilmot) by Monduzzi Ed.
Bologne, 89-94, 1998
OPTIMAL MANAGEMENT OF TUMORS IN THE SUPERIOR SULCUS
P. DARTEVELLE, P. MACCHIARINI
ADVANCED THERAPY IN THORACIC SURGERY. (Ed. KL Franco, JB Putman, HC)
M Decker Inc Publisher. Hamilton. 106-116, 1998
LUNG TRANSPLANTATION
P. MACCHIARINI, R. ORIOL
ADVANCED THERAPY IN THORACIC SURGERY. (Ed. KL Franco, JB Putman, HC)
M Decker Inc Publisher. Hamilton, 404-414, 1998
ARTICLES ORIGINAUX DANS DES REVUES INTERNATIONALES
INTERACTION BETWEEN TACROLIMUS AND ITRACONAZOLE IN
A HEART-LUNG TRANSPLANT RECIPIENT
V. FURLAN, F. PARQUIN, J.F. PENAUD, J. CERRINA, F. LE ROY LADURIE, P.
DARTEVELLE. AM TABURET.
TRANSPLANTATION PROCEEDINGS. 1998; 30:187-188.
LUNG
REPERFUSION INJURY AFTER CHRONIC OR ACUTE UNILATERAL PULMONARY ARTERY
OCCLUSION.
E. FADEL, GM. MAZMANIAN, A. CHAPELIER, B. BAUDET, H. DETRUIT, V. DE
MONTPREVILLE, JM. LIBERT, M. WARTSKI. P. HERVE. P. DARTEVELLE.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.
1998;157:1294-1300 (abstract)
LUNG REPERFUSION INJURY AFTER CHRONIC OR ACUTE
LUNG ISCHEMIA IN PIG : ROLE OF THE BRONCHIAL CIRCULATION
E. FADEL, GM. MAZMANIAN, P. HERVE, P. DARTEVELLE
J. OF VASCULAR RESEARCH. 35, S2, 1998 ; 012 #
PULMONARY THROMBOENDARTERIECTOMY USING
VIDEO-ANGIOSCOPY : An Alternative to cardiopulmonary transplant for
post-embolic pulmonary arterial hypertension.
P. DARTEVELLE, E. FADEL, A. CHAPELIER, P. MACCHIARINI
CARDIOVASCULAR INTERVENTIONS ONLINE + CD-Rom May 1998 n°
1
SURGERY FOR INVASIVE
PRIMARY MEDIASTINAL TUMORS
EA. BACHA, AR. CHAPELIER, P. MACCHIARINI, E. FADEL and PG.
DARTEVELLE
ANN. THORAC SURG 1998;66:234-239 (abstract)
EVIDENCE OF HUMAN
NON- Alpha-GALACTOSYL ANTIBODIES INVOLVED IN THE HYPERACUTE REJECTION
OF PIG LUNGS AND THEIR REMOVAL BY PIG ORGAN REPERFUSION.
P. MACCHIARINI, R. ORIOL, A. AZIMZADEH, V.DE MONTPREVILLE, R. RIEBEN,
M. MAZMANIAN, P. DARTEVELLE.
J. THORAC CARDIOVASC. SURG. 1998;116:841-843 (abstract)
TRACHEAL TRANSPLANTATION : BEYOND THE REPLACEMENT
OF A SIMPLE CONDUIT
P. MACCHIARINI
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
1998;14:621-623
Invited Commentary on : SUPERIOR VENA CAVAL
RECONSTRUTION USING AUTOLOGOUS PERICARDIUM.
A. CHAPELIER
ANN. THORAC SURG. 1998;66:291-293
XENOTRANSPLANTATION PROCEED WITH CAUTION
P. MACCHIARINI
NATURE. 1998;12:392
ARTICLES DANS DES REVUES NATIONALES.
THROMBO-ENDARTERIECTOMIE
PULMONAIRE SOUS VIDEO-ANGIOSCOPIE ET ARRET CIRCULATOIRE : UNE
ALTERNATIVE À LA TRANSPLANTATION CARDIO-PULMONAIRE DANS
L'HYPERTENSION ARTERIELLE PULMONAIRE POST-EMBOLIQUE.
P. DARTEVELLE, E. FADEL, A. CHAPELIER, P. MACCHIARINI, J. CERRINA, F.
LE ROY LADURIE, F. PARQUIN, F. SIMONNEAU, F. PARENT, M. HUMBERT, G.
SIMONNEAU.
CHIRURGIE 1998;123:32-40 (abstract)
THROMBO-ENDARTERIECTOMIE PULMONAIRE SOUS
VIDEO-ANGIOSCOPIE ET ARRET CIRCULATOIRE : UNE REELLE ALTERNATIVE
À LA TRANSPLANTATION CARDIO-PULMONAIRE DANS L'HYPERTENSION
ARTERIELLE PULMONAIRE POST-EMBOLIQUE.
P. DARTEVELLE, E. FADEL, A. CHAPELIER, P. MACCHIARINI, J. CERRINA, F.
LE ROY LADURIE, F. PARQUIN, F. SIMONNEAU, F. PARENT, M. HUMBERT, G.
SIMONNEAU.
LES ACTES DU 2e CONGRES DE PNEUMOLOGIE - Actualités (Ed. Margaux Orange) 1998;25-32
TUMEUR DESMOIDE DE LA
PAROI THORACIQUE. Un cas révélé par un
enraidissement douloureux de l'épaule.
JS GIRAUDET-LE QUIN TREC, A. MINOUI, E. FRENAUX, A. ANRACT, E. FADEL,
G. MISSENARD, M. KERBOULL, P. DARTEVELLE, A. KAHAN
LA PRESSE MEDICALE 1998;27:1727-30 (abstract)
INFECTIONS APRES TRANSPLANTATION D'ORGANE : QUELLE
PLACE POUR LA BIOLOGIE MOLECULAIRE ?
F. PARQUIN, J. CERRINA, F. LE ROY LADURIE, JM. LIBERT, P.
DARTEVELLE
LA LETTRE DE L'INFECTIOLOGUE.Tome XIII. 1998;2:85-
INFECTIONS PULMONAIRES APRES TRANSPLANTATION
PULMONAIRE
F. PARQUIN F. LE ROY LADURIE, J. CERRINA, JM. LIBERT, P.
DARTEVELLE
LES ACTES DU 2e CONGRES DE PNEUMOLOGIE - Aplasie fébrile et pneumopathie en onco-hématologie. (Ed. Margaux Orange). 1998; 301-307
EXERESES CHIRURGICALES ELARGIES DANS LE CANCER
BRONCHOPULMONAIRE
P. DARTEVELLE, P. MACCHIARINI, G. MISSENARD, A. CHAPELIER, E.
FADEL
LA LETTRE DU CANCEROLOGUE, Supp. Juin 1998; Vol. VII n° 3 - 16-21
CONFERENCES SUR INVITATION PAR UNIVERSITES ETRANGERES
ANTERIOR APPROACH SUPERIOR SULCUS TUMOR
P. DARTEVELLE
HAVARD MEDICAL SCHOOL Postgraduate Course in General Thoracic
Surgery. Boston 21-22 May 1998
CARINAL RESECTION FOR LUNG CANCER
P. DARTEVELLE
HAVARD MEDICAL SCHOOL Postgraduate Course in General Thoracic
Surgery. Boston 21-22 May 1998
MANAGEMENT OF ASPERGILLOMAS
P. DARTEVELLE
HAVARD MEDICAL SCHOOL Postgraduate Course in General Thoracic
Surgery. Boston 21-22 May 1998
SURGERY FOR CHRONIC PULMONARY THROMBOEMBOLIC
DISEASE
P. DARTEVELLE
HAVARD MEDICAL SCHOOL Postgraduate Course in General Thoracic
Surgery. Boston 21-22 May 1998
SUPERIOR VENA CAVA REPLACEMENT FOR MEDIASTINAL
TUMORS
P. DARTEVELLE
HAVARD MEDICAL SCHOOL Postgraduate Course in General Thoracic
Surgery. Boston 21-22 May 1998
SURGERY FOR LOCALLY ADVANCED LUNG CANCER
P. MACCHARINI
KANAZAWA UNIVERSITY, Kanazawa (japan) October 7, 1998
PRESENTATIONS A DES CONGRES INTERNATIONAUX
DARTEVELLE APPROACH TO APICAL TUMORS
P. DARTEVELLE
34th Meeting of THE SOCIETY OF THORACIC SURGEONS. New Orleans..
January 26-28, 1998
AN EXPERIMENTAL MODEL OF THROMBOENDARTERECTOMY FOR
CHRONIC THROMBOTIC PULMONARY OBSTRUCTION IN THE PIGLET
E. FADEL, JY. RIOU, E. BACHA, P. BRENOT, P. HERVE, GM MAZMANIAN , P.
DARTEVELLE.
XXXIIIrd Congress of The EUROPEAN SOCIETY FOR SURGICAL RESEARCH.
Padua (italy) April 22-25, 1998
LUNG REPERFUSION INJURY AFTER CHRONIC OR ACUTE
PULMONARY ARTERY OCCLUSION.
E. FADEL, GM MAZMANIAN, J. CERRINA, F. PARQUIN, P. HERVE, P.
DARTEVELLE
AMERICAN THORACIC SOCIETY International Conference. Chicago. April
24-29, 1998
EFFECT OF DEXFENFLURAMINE IN THE FAWN HOODED
RAT.
R. GALLIOT, M. MAZMANIAN, JM. LAUNAY, D. RAVEL, J. CERRINA, P.
HERVE
AMERICAN THORACIC SOCIETY International Conference. Chicago. April
24-29, 1998
PIG LUNG PRE-PERFUSION PREVENTS LUNG HYPERCUTE
REJECTION IN THE PIG-TO-HUMAN COMBINATION
P. MACCHIARINI, R. ORIOL, R. RIEBEN, N. BOVIN an P. DARTEVELLE,. Le
Plessis Robinson and Villejuif (France) Berne (Switzerland) and
Moscow (Russia).
THE AMERICAN ASSOCIATION FOR THORACIC SURGERY. 78th Annual Meeting.
Boston 3-6 May 1998.
TRANSCERVICAL THORACIC APPROACH FOR RESECTING
MALIGNANT TUMORS T3-T4 INVADING TRHE THORACIC INLET
P. DARTEVELLE
Second International Congress of THORAX SURGERY - Bologna June 24-26,
1998
SURGICAL TREATMENT OF CHRONIC THROMBO-EMBOLIC
PULMONARY DISEASE
P. DARTEVELLE
Second International Congress of THORAX SURGERY - Bologna June 24-26,
1998
LUNG AND HEART-LUNG TRANSPLANTATION
P. DARTEVELLE
Second International Congress of THORAX SURGERY - Bologna June 24-26,
1998
LOW SPECIFICITY AND SENSITIVITY OF GALLIUM-67 SCAN
IN THE EVALUATION OF POST CHEMOTHERAPY MEDIASTINAL RESIDUAL MASSES IN
AGGRESSIVE NON HODGKIN'S LYMPHOMA.
A. ULUSAKARYA, JN. MUNCK, O. CASIRAGHI, S. KOSCIELNY, JM. VANTELON,
P. DARTEVELLE, T. GRINSKY, P. CARDE, M. HAYAT
I.S.H. - E. H. A Amsterdam. 4-8 July, 1998
LUNG REPERFUSION INJURY AFTER CHRONIC OR ACUTE
LUNG ISCHEMIA IN PIG : ROLE OF THE BRONCHIAL CIRCULATION
E. FADEL
20th European Conference on MICROCIRCULATION . Paris 20 août-2
sept. 1998
ANGIOSCOPIC VIDEO-ASSISTED PULMONARY
ENDARTERECTOMY FOR CHRONIC POST-EMBOLIC PULMONARY HYPERTENSION
P. DARTEVELLE, E. FADEL, A. CHAPELIER, P. MACCHIARINI, F. PARENT,
G.SIMONNEAU
EUROPEAN RESPIRATORY SOCIETY - Annual Congress Geneva Sepember 19-23,
1998
RESULTS OF LUNG TRANSPLANTATION FOR PRIMARY
PULMONARY HYPERTENSION
F. LE ROY LADURIE, J. CERRINA, A. CHAPELIER, F. PARQUIN, E. FADEL, P.
MACCHIARINI, P. DARTEVELLE
EUROPEAN RESPIRATORY SOCIETY - Annual Congress Geneva Sepember 19-23,
1998
ANGIOSCOPIC VIDEO-ASSISTED PULMONARY
ENDARTERECTOMY FOR CHRONIC POST-EMBOLIC PULMONARY HYPERTENSION
P. DARTEVELLE, E. FADEL, A. CHAPELIER, P; MACCHIARINI, F. SIMONNEAU,
F. PARQUIN
12TH Annual Meeting of the E.A.C.T.S. - Brussels 20-23 september
1998
CLAMSHELL OR STERNOTOMY FOR DOUBLE LUNG OR
HEART-LUNG TRAN SPLANTATION
P. MACCHIARINI, F. LE ROY LADURIE, J. CERRINA, E. FADEL, A.
CHAPELIER, P. DARTEVELLE
12TH Annual Meeting of the E.A.C.T.S. - Brussels 20-23 september
1998
SURGICAL MANAGEMENT OF STAGE IIIB and IV LUNG
CANCER
P. MACCHIARINI
51st Annual Scientific meeting of The JAPANESE ASSOCIATION FOR
THORACIC SURGERY Tokyo - 2-4 October 1998
THE FUTURE OF LUNG TRANSPLANTATION : LUNG
XENOTRANSPLANTATION.
P. MACCHIARINI
51st Annual Scientific meeting of The JAPANESE ASSOCIATION FOR
THORACIC SURGERY Tokyo - 2-4 October 1998
ABDOMINAL TRANSDIAPHRAGMATIQUE APPROACH FOR
RESECTION OF NODES LOCATED IN THE POSTERIOR MEDIASTINUM IN TESTIS
CANCER.
E. FADEL
4TH International Congress on New Technology in Surgery : "SURGERY
MEETS HIGH-TECH IN THE INFORMATION AGE" Munich December 9-12,
1998
SUPERIOR VENA CAVA REPLACEMENT FOR RESECTION OF
MEDIASTINAL AND LUNG CANCER : INDICATIONS. TECHNICS AND RESULTS.
P. MACCHIARINI
4TH International Congress on New Technology in Surgery : "SURGERY
MEETS HIGH-TECH IN THE INFORMATION AGE" Munich December 9-12,
1998
CHEST WALL RESECTION IN LUNG CANCER. TECHNICS AND
RESULTS.
A. CHAPELIER
4TH International Congress on New Technology in Surgery : "SURGERY
MEETS HIGH-TECH IN THE INFORMATION AGE" Munich December 9-12,
1998
ANTERIOR TRANSCERVICAL APPROACH FOR RESECTION OF
LUNG CANCER INVADING THE THORACIC INLET.
P. DARTEVELLE
4TH International Congress on New Technology in Surgery : "SURGERY
MEETS HIGH-TECH IN THE INFORMATION AGE" Munich December 9-12,
1998
PULMONARY THROMBO-ENDARTERIECTOMY USING
VIDEO-ASSISTED SURGERY : AN ALTERNATIVE TO LUNG TRANSPLANTATION.
P. DARTEVELLE
4TH International Congress on New Technology in Surgery : "SURGERY
MEETS HIGH-TECH IN THE INFORMATION AGE" Munich December 9-12,
1998
HEART-LUNG TRANSPLANTATION FOR VASCULAR
DISEASES
P. DARTEVELLE
4TH International Congress on New Technology in Surgery : "SURGERY
MEETS HIGH-TECH IN THE INFORMATION AGE" Munich December 9-12,
1998
PRESENTATION A DES CONGRES NATIONAUX
THROMBO-ENDARTERIECTOMIE PULMONAIRE SOUS
VIDEO-ANGIOSCOPIE ET ARRET CIRCULATOIRE. UNE ALTERNATIVE A LA
TRANSPLANTATION CARDIOPULMONAIRE DANS L'HYPERTENSION ARTERIELLE
PULMONAIRE POST-EMBOLIQUE
P. DARTEVELLE, E. FADEL, A. CHAPELIER, P. MACCHIARINI, J. CERRINA, F.
LE ROY LADURIE, F. PARQUIN, F. SIMONNEAU, F. PARENT, M. HUMBERT, G.
SIMONNEAU
ACADEMIE DE CHIRURGIE - Paris 14 Janvier 1998
THROMBO-ENDARTERIECTOMIE PULMONAIRE VIDEO-ASSISTEE
DANS LA MALADIE THROMBO-EMBOLIQUE.
P. DARTEVELLE
2e Congrès de PNEUMOLOGIE DE LANGUE FRANCAISE. Nice 21-24 Janvier 1998
INFECTIONS PULMONAIRES APRES TRANSPLANTATION
PULMONAIRE
F. PARQUIN
2e Congrès de PNEUMOLOGIE DE LANGUE FRANCAISE. Nice 21-24 Janvier 1998
ABORD CERVICO-THORACIQUE ELARGI
A. CHAPELIER, P. DARTEVELLE
INTERNATIONAL THORAX SYMPOSIUM. La paroi Thoracique et ses Voies d'Abord : Approches Multidisciplinaires. Abbaye des Vaux de Cernay. 6-7 Mars 1998
LA THROMBO-ENDARTERIECTOMIE PULMONAIRE
P. DARTEVELLE
Congrès AFiCCT - Société de Chirurgie Thoracique et Cardio-Vasculaire de Langue Française - Saint Malo 4-5 Juin 1998
L'HYPERTENSION ARTERIELLE PULMONAIRE
POST-EMBOLIQUE : PLACE DE LA CHIRURGIE
P. DARTEVELLE
Les Rencontres Pneumologiques de l'Hôpital Saint Joseph - Marseille 16 Novembre 1998
TF1 JOURNAL TELEVISE 20 h. :14 janvier 1998 Invité P. DARTEVELLE "A propos de la greffe de larynx "
FRANCE 2 : "SAVOIR PLUS SANTE" 6 juin 1998 "Les as de la chirurgie" présenté par M. ALLAIN-REGNAULT - F. DE CLOSETS invités H. BISMUTH, A. CARPENTIER, P. DARTEVELLE,
THROMBO-ENDARTERIECTOMIE PULMONAIRE SOUS VIDEO-ANGIOSCOPIE
IMPACT MEDECIN HEBDO Pages Spéciales "La Pneumologie en 1998" n° 398 27 Février 1998 - p. 19
SEMINAIRE D'ENSEIGNEMENT DU COLLEGE ET DU CES DE
CHIRURGIE THORACIQUE ET CARDIO-VASCLAIRE - 24 Avril 1998
- CHIRURGIE DE LA JONCTION CERVICO-THORACIQUE . P.
DARTEVELLE
DES DE CHIRURGIE GENERALE - Séminaire
Vasculaire et Thoracique.
- LES LIMITES CHIRURGICALES DE L'EXERESE PULMONAIRE : A.
CHAPELIER
DCEM2 - UNIVERSITE PARIS-SUD
- TRAUMATISMES THORACIQUES : E.FADEL
- CANCER BRONCHO-PULMONAIRE : A. CHAPELIER
PCEM2 - DCEM1 - Faculté de Médecine
Pitié Salpétrière
- ENSEIGNEMENT DE L'ANATOMIE : E. FADEL
MAITRISE D'ANATOMIE ET D'EMBRYOGENESE
Faculté de Médecine Pitié
Salpétrière
E. FADEL
DIPLOME D'UNIVERSITE DE CARCINOLOGIE
CERVICO-FACIALE - UFR Médicale de l'Université
Paris-Sud - Institut Guastave Roussy - : P. DARTEVELLE
LES TUMEURS DE LA JONCTION CERVICO-THORACIQUE
DIPLOME D'UNIVERSITE ANGIO-ANATOMIE HUMAINE.
Université Paris Sud : A. CHAPELIER
- L'AORTE THORACIQUE
- L'AORTE ABDOMINALE : APPLICATION A LA CHIRURGIE
- LES VAISSEAUX PULMONAIRES : ARTERE, VEINE PULMONAIRE, ARTERES
BRONCHIQUES : APPLICATIONS A LA TRANSPLANTATION.
Réunion du GROUPE D'ONCOLOGIE THORACIQUE DE
LA SOCIETE DE PNEUMOLOGIE DE LANGUE FRANCAISE (G.O.L.F.) Saint Brieuc
2-3 Avril 1998
- SYNDROME DE PANCOAST-TOBIAS : CHIRURGIE. P.
DARTEVELLE
10ème JOURNEE de BICETRE - LES PRELEVEMENTS
D'ORGANES EN VUE DE TRANSPLANTATION - 18 JUIN 1998
- EVALUATION DU GREFFON PULMONAIRE AU COURS DU PRELEVEMENT, SON
IMPACT SUR LES RESULTATS DE LA TRANSPLANTATION PULMONAIRE OU
CARDIO-PULMONAIRE. A. CHAPELIER
ACTUALITES EN PATHOLOGIE THORACIQUE ET
CARDIO-VASCULAIRE. CHU CAEN 3 Juin 1998
- CHIRURGIE DE L'HTAP POST-EMBOLIQUE : L'ENDARTERIECTOMIE PULMONAIRE
VIDEO-ASSISTEE ALTERNATIVE À LA TRANSPLANTATION
CARDIO-PULMONAIRE : P. DARTEVELLE
TRAITEMENT CHIRURGICAL DU CPC POST-EMBOLIQUE
P. DARTEVELLE - Staff de Médecine Interne - Hôpital de
Bicêtre. 21 Octobre 1998
HABILITATION A DIRIGER DES RECHERCHES
DE L'ALLOTRANSPLANTATION TRACHEALE ET TRACHEO-ŒSOPHAGIENNE A LA XENOTRANSPLANTATION PULMONAIRE : Paolo MACCHIARINI
Faculté de Médecine paris-Sud - 16 Décembre 1998
TRAITEMENT CHIRURGICAL DES COMPLICATIONS
TRACHEALES DE LA VENTILATION ASSISTEE : Jean Philippe VERHOYE
Faculté de Médecine de Rennes. 16 Octobre
1998
LES TERATOMES MATURES DU MEDIASTIN. ANALYSE
RETROSPECTIVE D'UNE SERIE DE 17 CAS OPERES SUR UNE PERIODE DE 19 ANS
: Mathieu BESNARD
Faculté de Médecine de Cochin-Port Royal. 22 Octobre
1998
SARCOME DE L'ARTERE PULMONAIRE : A PROPOS DE 3 CAS
ET REVUE DE LA LITTERATURE : Aurélie LEFEVRE
Faculté de Médecine Paris-Ouest. 22 Octobre
1998
BACKGROUND: There have been few reports on results after extended radical resection for primary mediastinal tumors invading neighboring organs. METHODS: A retrospective analysis of 89 patients who underwent total or subtotal resection of a primary mediastinal tumor with resection of at least part of an adjacent structure between 1979 and 1995 was performed. Clinical data were collected from the medical records. RESULTS: There were 35 invasive thymomas, 12 thymic carcinomas, 17 germ cell tumors, 16 lymphomas, 3 neurogenic tumors, 3 thyroid carcinomas, 2 radiation-induced sarcomas, and 1 mediastinal mesothelioma. The tumor was located in the anterior mediastinum in 74% of patients. Residual masses after chemotherapy were excised in 14 patients with germ cell tumor and 8 with lymphoma. A median sternotomy was the most frequently used approach (79% of patients). Total resection was achieved in 79% and significantly improved survival (p < 0.01). Adjacent resected structures included 38 phrenic nerves, 21 superior venae cavae, 16 upper lobes, and 13 innominate veins, in 5 patients, a pneumonectomy was required. The complication rate was 17% and the mortality rate, 6%. With follow-up available for 86 patients, the overall 5-year survival rate was 69% for patients with thymoma, 42% for patients with thymic carcinoma, 48% for patients with germ cell tumor, and 83% for patients with lymphoma. CONCLUSIONS: Malignant mediastinal tumors can be safely resected even if they have invaded other mediastinal structures. Complete resection is important to achieve satisfactory long-term survival. A median sternotomy is an excellent approach, and a preoperative diagnosis by biopsy is desirable. Residual masses after chemotherapy for lymphoma or germ cell tumor should be resected. Extensive resection without a preoperative diagnosis is not indicated
BACKGROUND: Desmoid tumors are uncommon fibromatous tumors arising from musculoaponeurotic tissue characterized by spindle cell fibroblast and myofibroblast proliferation. The cause is unknown (trauma, hormonal factors, genetic anomaly...). Locally invasive, they tend to recur increasing morbidity or even mortality. CASE REPORT: Stiff shoulder resulting from blockage of the scapulothoracic articulation was the inaugural sign. Three-phase bone scintigraphy demonstrated early uptake in the soft tissue in contact with the scapula. Magnetic resonance imaging and biopsy confirmed the diagnosis of desmoid tumor. Complete resection was performed. No adjuvant radiotherapy nor hormone treatment were given since no antiestrogen receptor antibodies were identified on the surgical specimen. DISCUSSION: The clinical manifestation (stiff shoulder) and the scapular localization observed in this case are unusual for desmoid tumors. Initially tendinopathy of the shoulder, acromio-clavicular arthropathy and capsular retraction of the shoulder joint had been entertained. Early diagnosis and wide surgical resection are indicated in desmoid tumors.
BACKGROUND: Human natural xenoantibodies represent a major hurdle to the clinical application of pig lungs in transplantation by initiating hyperacute rejection within minutes to hours. OBJECTIVE: The object was to compare pig organ perfusion and specific depletion of anti-alpha-galactosyl xenoantibodies for prevention of hyperacute rejection in the pig to human lung combination. METHODS: Large White pig (20-25 kg) left lungs were removed and continuously ventilated and reperfused ex vivo either with (1) whole human blood previously perfused in situ through pig right lung (group I), liver (group II), or spleen (group III) or with (2) human plasma in vitro immunoabsorbed on columns containing alpha-galactosyl disaccharide (Gal-alpha-(1-3)Gal-beta-(CH2)3NH2; B disaccharide) (group IV). Each study group included 6 animals. RESULTS: The in situ and in vitro preperfusions depleted anti-alpha-galactosyl xenoantibodies and all in situ perfused pig organs showed histologic signs of hyperacute rejection. After the ex vivo reperfusion, group I xenografts had a significantly (P < .001) longer functional and histologic survival than did xenografts in groups II, III, and IV. Human blood reperfusing group I xenografts had a significantly (P < 0.05) lower (1) decline of clotting factors and total circulating immunoglobulins, (2) total andmembrane attack complex (C5b,6,7,8,9) complement activation, and (3) hemolysis. By Western blot analysis, the in situ lung preperfusion removed antibodies against non-alpha-galactosyl proteins of low molecular weight that were not eliminated by the alpha-galactosyl column. CONCLUSIONS: Results demonstrate that specific depletion of anti-alpha-galactosyl antibodies alone incompletely protects pig lungs from hyperacute rejection. It is speculated that the more complete prevention of this rejection afforded by pig lung preperfusion relates to the removal of other, non-alpha-galactosyl antibodies
The best predictor of poor or suboptimum outcome from pulmonary thromboendarterectomy (PTE) is insufficient relief of obstruction, especially in the lower lobes. The aim of this study is to emphasize that the use of video-assisted angioscopy may increase the quality of PTE and thus improve outcome. PTE included a median sternotomy, intrapericardial dissection limited to the superior vena cava, institution of cardiopulmonary bypass, deep hypothermia and sequential circulatory arrest periods. PTE was always bilateral and performed through two separate arteriotomies of both main intrapericardial pulmonary arteries. A rigid 5 mm angioscope connected to a video camera was introduced through the arteriotomy into the lumen to increase the visibility and perform the video-assisted endarterectomies of all obstructed segmental branches, including normally inaccessible anterior segmental branches. Between January 1996 and December 1997, 48 patients with severe postembolic pulmonary hypertension had PTE. Patients were in New York Heart Association (NYHA) class II (n = 2), III (n = 28) or IV (n = 18) with the following hemodynamics: mean pulmonary arterial pressure (PAP) 53 +/- 13 mmHg, cardiac index 2.16 +/- 0.5 L/min/m2, pulmonary vascular resistances (PVR): 1,152 +/- 414 dyne.s-1.cm-5. Six patients died from alveolar hemorrhage (n = 1), high residual pulmonary pressure and rethrombosis (n = 4) and hypoxic cardiac arrest (n = 1). The functional outcome in surviving patients was as follows: (NYHA) class I (n = 24), II (n = 16) or III (n = 2) with improved hemodynamics: mean pulmonary arterial pressure: 30 +/- 9 mmHg, cardiac index: 2.78 +/- 0.5 L/min/m2, pulmonary vascular resistances (PVR): 484 +/- 159 dynes.s-1.cm-5. Video-assisted angioscopy allows much improved quality and degree of pulmonary endarterectomy. This expands the indications to include patients with previously inaccessible distal disease and candidates for heart-lung transplantation.
Because the lungs receive their blood supply from both the pulmonary and bronchial systems, chronic pulmonary artery obstruction does not necessarily result in severe ischemia. Ischemia-reperfusion (IR) lung injury may therefore be attenuated after long-term pulmonary artery obstruction. To test this hypothesis, isolated left lungs of pigs were reperfused two days (acute IR group) or 5 wk (chronic IR group) after left pulmonary artery ligation and compared to those of sham-operated animals. The severity of IR-lung injury after 60 min ex vivo reperfusion of the left lung was assessed based on lung histology and measurements of filtration coefficient (Kfc), pulmonary arterial resistance (Rpa), and lung myeloperoxidase (MPO) activity. Marked bronchial circulation hypertrophy was seen in the chronic IR group. Hemorrhagic alveolar edema was found in all acute IR lungs but not in sham or chronic IR lungs. Compared with the sham-operated controls, Kfc and Rpa increased two-fold and threefold, and MPO 1.5-fold and twofold in the chronic and acute IR groups, respectively. In conclusion, IR-induced lung injury was markedly reduced when it occurred 5 wk after pulmonary artery ligation, probably because the systemic blood supply to the lung had time to develop, limiting ischemia.